Exon junction complex enhances translation of spliced mRNAs at multiple steps
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyung Chul | - |
dc.contributor.author | Choe, Junho | - |
dc.contributor.author | Chi, Sung-Gil | - |
dc.contributor.author | Kim, Yoon Ki | - |
dc.date.accessioned | 2021-09-08T15:36:38Z | - |
dc.date.available | 2021-09-08T15:36:38Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-07-03 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/119685 | - |
dc.description.abstract | Translation of spliced mRNAs is enhanced by exon junction complex (EJC), which is deposited on mRNAs as a result of splicing. Although this phenomenon itself is well known, the underlying molecular mechanism remains Poorly understood. Here we show, using siRNAs against Y14 and eIF4AIII and spliced or intronless Constructs that contain different types of internal ribosome entry sites (IRESes), that Y14 and eIF4AIII increase translation of spliced mRNAs before and after formation of the 80S ribosome complex, respectively. These results suggest that EJC modulates translation of spliced mRNA at multiple steps. (C) 2009 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | QUALITY-CONTROL | - |
dc.subject | PROTEIN | - |
dc.subject | INITIATION | - |
dc.subject | MACHINERY | - |
dc.subject | NUCLEUS | - |
dc.subject | CELLS | - |
dc.subject | DECAY | - |
dc.subject | UPF1 | - |
dc.title | Exon junction complex enhances translation of spliced mRNAs at multiple steps | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chi, Sung-Gil | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Ki | - |
dc.identifier.doi | 10.1016/j.bbrc.2009.04.123 | - |
dc.identifier.scopusid | 2-s2.0-65649092162 | - |
dc.identifier.wosid | 000266647400012 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.384, no.3, pp.334 - 340 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 384 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 334 | - |
dc.citation.endPage | 340 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | QUALITY-CONTROL | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | INITIATION | - |
dc.subject.keywordPlus | MACHINERY | - |
dc.subject.keywordPlus | NUCLEUS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DECAY | - |
dc.subject.keywordPlus | UPF1 | - |
dc.subject.keywordAuthor | elF4AIII | - |
dc.subject.keywordAuthor | Y14 | - |
dc.subject.keywordAuthor | Exon junction complex | - |
dc.subject.keywordAuthor | Nonsense-mediated mRNA decay | - |
dc.subject.keywordAuthor | Splicing | - |
dc.subject.keywordAuthor | Internal ribosome entry site | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.