Human papillomavirus 16 and 18 L1 serology in Korean women with high-grade cervical intraepithelial neoplasia and cervical cancer
DC Field | Value | Language |
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dc.contributor.author | Jeong, Nan-Hee | - |
dc.contributor.author | Woo, Mi-Kyung | - |
dc.contributor.author | Lee, Nak-Woo | - |
dc.contributor.author | Hur, Sook-Jin | - |
dc.contributor.author | Choi, Kum-Sook | - |
dc.contributor.author | Kim, Hong-Jin | - |
dc.date.accessioned | 2021-09-08T15:39:42Z | - |
dc.date.available | 2021-09-08T15:39:42Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-07 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/119701 | - |
dc.description.abstract | We aimed to determine the prevalence of HPV-16/18 antibodies in Korean women with high-grade cervical intraepithelial neoplasia (CIN) and cervical cancer. We conducted the hospital-based case-control study at the university hospital between 2003 and 2006. Cases were 130 high-grade CIN and 43 cervical cancer patients and the control group was 106 women showing normal cervical cytology. Enzyme-linked immunosorbent assays were performed for HPV-16/18 L1 virus-like particles (VLPs) as an antigen. Seropositivity for HPV-16 VLP and HPV-18 VLP was found in 67.4% and 30.2% of cancer patients and 59.2% and 20.0% of high-grade CIN patients, respectively. Seropositivity for HPV-16 with high-grade CIN (OR 6.91; 95% CI 3.74-12.76) and cervical cancer (OR 8.99; 95% CI 3.88-20.84) presented significant associations, as did seropositivity for HPV-18 (high-grade CIN: OR 3.64; 95% CI 1.67-7.95, cervical cancer: OR 6.82; 95% CI 2.52-18.45). Patients with both HPV-16 and 18 seropositivity were 9.38 times (95% CI 2.98-29.51) more likely to have high-grade CIN and 17.05 times (95% CI 4.55-63.87) more likely to have cancer. Both HPV 16 and 18 L1 VLP serology is the clear disease predictors of presence of high-grade CIN and cervical cancer. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.subject | VIRUS-LIKE PARTICLES | - |
dc.subject | SACCHAROMYCES-CEREVISIAE | - |
dc.subject | SERUM ANTIBODIES | - |
dc.subject | YOUNG-WOMEN | - |
dc.subject | G RESPONSES | - |
dc.subject | TYPE-16 | - |
dc.subject | INFECTION | - |
dc.subject | ASSAY | - |
dc.subject | RISK | - |
dc.subject | SEROREACTIVITY | - |
dc.title | Human papillomavirus 16 and 18 L1 serology in Korean women with high-grade cervical intraepithelial neoplasia and cervical cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Nak-Woo | - |
dc.identifier.doi | 10.1007/s12272-009-1706-z | - |
dc.identifier.scopusid | 2-s2.0-68649101473 | - |
dc.identifier.wosid | 000268511000008 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.32, no.7, pp.1013 - 1018 | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 32 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1013 | - |
dc.citation.endPage | 1018 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001364347 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | VIRUS-LIKE PARTICLES | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | SERUM ANTIBODIES | - |
dc.subject.keywordPlus | YOUNG-WOMEN | - |
dc.subject.keywordPlus | G RESPONSES | - |
dc.subject.keywordPlus | TYPE-16 | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | ASSAY | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | SEROREACTIVITY | - |
dc.subject.keywordAuthor | Cervical cancer | - |
dc.subject.keywordAuthor | Cervical intraepithelial neoplasia | - |
dc.subject.keywordAuthor | Enzyme-linked immunosorbent assay | - |
dc.subject.keywordAuthor | Human papillomavirus | - |
dc.subject.keywordAuthor | Serology | - |
dc.subject.keywordAuthor | Virus-like particles | - |
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