Impact of the tryptophan hydroxylase 1 gene A218C polymorphism on amygdala activity in response to affective facial stimuli in patients with major depressive disorder
- Authors
- Lee, B. -T.; Lee, H. -Y.; Lee, B. -C.; Pae, C. -U.; Yoon, B. -J.; Ryu, S. -G.; Choi, I. -G.; Lee, M. -S.; Ham, B. -J.
- Issue Date
- 7월-2009
- Publisher
- WILEY
- Keywords
- Functional magnetic resonance imaging; major depressive disorder; polymorphism; sadness; anger; tryptophan hydroxylase
- Citation
- GENES BRAIN AND BEHAVIOR, v.8, no.5, pp.512 - 518
- Indexed
- SCIE
SCOPUS
- Journal Title
- GENES BRAIN AND BEHAVIOR
- Volume
- 8
- Number
- 5
- Start Page
- 512
- End Page
- 518
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/119708
- DOI
- 10.1111/j.1601-183X.2009.00500.x
- ISSN
- 1601-1848
- Abstract
- Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the TPH1 locus have been implicated in the pathophysiology of depression. Using 1.5-Tesla functional magnetic resonance imaging, we investigated the possible relationship between TPH1 A218C polymorphism and amygdala response to negative facial stimuli in 26 right-handed female subjects with major depressive disorder (MDD). Genotyping was performed with the polymerase chain reaction. We found a significant association between A allele of the TPH1 A218C polymorphism and neural activations in response to negative facial stimuli. Subjects with the A allele of the TPH1 A218C polymorphism showed greater brain activity in the bilateral amygdala under the sad vs. the neutral condition compared with subjects homozygous for the C allele. Our results suggest that the A218C polymorphism of the TPH1 gene serves as a modulator of amygdala activity in patients with MDD.
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Collections - College of Life Sciences and Biotechnology > Division of Life Sciences > 1. Journal Articles
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- Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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