Inhibition of Lung Metastasis in Mice by Oligonol
- Authors
- Lee, Sung-Jae; Chung, Ill-Min; Kim, Min-Young; Park, Keum-Duk; Park, Won-Hwan; Moon, Hyung-In
- Issue Date
- 7월-2009
- Publisher
- WILEY
- Keywords
- Oligonol; lung metastasis; antimetastatic activity
- Citation
- PHYTOTHERAPY RESEARCH, v.23, no.7, pp.1043 - 1046
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHYTOTHERAPY RESEARCH
- Volume
- 23
- Number
- 7
- Start Page
- 1043
- End Page
- 1046
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/119764
- DOI
- 10.1002/ptr.2810
- ISSN
- 0951-418X
- Abstract
- Oligonol is a polyphenol formulation enriched with catechin-type oligomers. As an initial approach to assess the chemopreventive potential of Oligonol, the study investigated the effects of Oligonol on the inhibition of lung metastasis induced by B16F-10 melanoma cells in C57BL/6 mice. Oligonol, which is abundantly found in plants, vegetables and fruits, was found to possess antimetastatic activity against B16F-10 melanoma cells. Continued consumption of Oligonol, even at high doses, for long periods does not seem to cause any toxic symptoms because excess Oligonol is stored in adipose tissue rather than in the liver. However, the mechanism by which Oligonol exerts its antimetastatic activity remains unclear. Further investigations are required to clarify the exact role of Oligonol in such B16F-10 melanoma regulation. Copyright (C) 2009 John Wiley & Sons, Ltd.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.