Decrease in the Kainate-Induced Wet Dog Shake Behavior in Genetically Epilepsy-Prone Rats: Possible Involvement of an Impaired Synaptic Transmission to the 5-HT2A Receptor
DC Field | Value | Language |
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dc.contributor.author | Shin, Eun-Joo | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.contributor.author | Chung, Yoon Hee | - |
dc.contributor.author | Kim, Tae-Woo | - |
dc.contributor.author | Shin, Chan Young | - |
dc.contributor.author | Kim, Won-Ki | - |
dc.contributor.author | Ko, Kwang-Ho | - |
dc.contributor.author | Kim, Hyoung-Chun | - |
dc.date.accessioned | 2021-09-08T16:00:39Z | - |
dc.date.available | 2021-09-08T16:00:39Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-07 | - |
dc.identifier.issn | 1347-8613 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/119790 | - |
dc.description.abstract | Genetically epilepsy-prone rats (GEPR-9s) were derived from Sprague-Dawley rats (SD). The number of kainate-induced wet dog shake behavior (WDS) responses was found to decrease significantly in GEPR-9s compared to SD. WDS responses were potentiated by 5-hydroxytryptophan or 2,5-dimethoxy-4-iodoamphetamine and antagonized by ritanserin. The antagonizing effect of ritanserin on WDS latency was more evident in GEPR-9s than in SD, and hippocampal expression of activity-regulated cytoskeleton-associated protein paralleled the severity of WDS. The results Suggest that downstream serotonergic synaptic activation is less pronounced in GEPR-9s than in SD and that the serotonergic agent may directly activate postsynaptic 5-HT2A receptors in both strains. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | JAPANESE PHARMACOLOGICAL SOC | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | ARC GENE | - |
dc.subject | SEIZURE | - |
dc.subject | DENDRITES | - |
dc.subject | BRAIN | - |
dc.title | Decrease in the Kainate-Induced Wet Dog Shake Behavior in Genetically Epilepsy-Prone Rats: Possible Involvement of an Impaired Synaptic Transmission to the 5-HT2A Receptor | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Won-Ki | - |
dc.identifier.doi | 10.1254/jphs.09015SC | - |
dc.identifier.scopusid | 2-s2.0-67749120525 | - |
dc.identifier.wosid | 000268413500023 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHARMACOLOGICAL SCIENCES, v.110, no.3, pp.401 - 404 | - |
dc.relation.isPartOf | JOURNAL OF PHARMACOLOGICAL SCIENCES | - |
dc.citation.title | JOURNAL OF PHARMACOLOGICAL SCIENCES | - |
dc.citation.volume | 110 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 401 | - |
dc.citation.endPage | 404 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | ARC GENE | - |
dc.subject.keywordPlus | SEIZURE | - |
dc.subject.keywordPlus | DENDRITES | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordAuthor | kainic acid | - |
dc.subject.keywordAuthor | genetically epilepsy-prone rat | - |
dc.subject.keywordAuthor | wet dog shake | - |
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