Triple Versus Dual Antiplatelet Therapy in Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chen, Kang-Yin | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Li, Yong-Jian | - |
dc.contributor.author | Poddar, Kanhaiya L. | - |
dc.contributor.author | Jin, Zhe | - |
dc.contributor.author | Minami, Yoshiyasu | - |
dc.contributor.author | Wang, Lin | - |
dc.contributor.author | Kim, Eung Ju | - |
dc.contributor.author | Park, Chang Gyu | - |
dc.contributor.author | Seo, Hong Seog | - |
dc.contributor.author | Oh, Dong Joo | - |
dc.contributor.author | Jeong, Myung Ho | - |
dc.contributor.author | Ahn, Young Keun | - |
dc.contributor.author | Hong, Taek Jong | - |
dc.contributor.author | Kim, Young Jo | - |
dc.contributor.author | Hur, Seung Ho | - |
dc.contributor.author | Seong, In Whan | - |
dc.contributor.author | Chae, Jei Keon | - |
dc.contributor.author | Cho, Myeong Chan | - |
dc.contributor.author | Bae, Jang Ho | - |
dc.contributor.author | Choi, Dong Hoon | - |
dc.contributor.author | Jang, Yang Soo | - |
dc.contributor.author | Chae, In Ho | - |
dc.contributor.author | Kim, Chong Jin | - |
dc.contributor.author | Yoon, Jung Han | - |
dc.contributor.author | Chung, Wook Sung | - |
dc.contributor.author | Seung, Ki Bae | - |
dc.contributor.author | Park, Seung Jung | - |
dc.date.accessioned | 2021-09-08T16:03:49Z | - |
dc.date.available | 2021-09-08T16:03:49Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-06-30 | - |
dc.identifier.issn | 0009-7322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/119807 | - |
dc.description.abstract | Background-Whether triple antiplatelet therapy is superior or similar to dual antiplatelet therapy in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention in the era of drug-eluting stents remains unclear. Methods and Results-A total of 4203 ST-segment elevation myocardial infarction patients who underwent primary percutaneous coronary intervention with drug-eluting stents were analyzed retrospectively in the Korean Acute Myocardial Infarction Registry (KAMIR). They received either dual (aspirin plus clopidogrel; dual group; n=2569) or triple (aspirin plus clopidogrel plus cilostazol; triple group; n=1634) antiplatelet therapy. The triple group received additional cilostazol at least for 1 month. Various major adverse cardiac events at 8 months were compared between these 2 groups. Compared with the dual group, the triple group had a similar incidence of major bleeding events but a significantly lower incidence of in-hospital mortality. Clinical outcomes at 8 months showed that the triple group had significantly lower incidences of cardiac death (adjusted odds ratio, 0.52; 95% confidence interval, 0.32 to 0.84; P=0.007), total death (adjusted odds ratio, 0.60; 95% confidence interval, 0.41 to 0.89; P=0.010), and total major adverse cardiac events (adjusted odds ratio, 0.74; 95% confidence interval, 0.58 to 0.95; P=0.019) than the dual group. Subgroup analysis showed that older (>65 years old), female, and diabetic patients got more benefits from triple antiplatelet therapy than their counterparts who received dual antiplatelet therapy. Conclusions-Triple antiplatelet therapy seems to be superior to dual antiplatelet therapy in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention with drug-eluting stents. These results may provide the rationale for the use of triple antiplatelet therapy in these patients. (Circulation. 2009; 119: 3207-3214.) | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | ELUTING STENT IMPLANTATION | - |
dc.subject | BARE METAL STENT | - |
dc.subject | PLATELET-AGGREGATION | - |
dc.subject | DIABETIC-PATIENTS | - |
dc.subject | CILOSTAZOL | - |
dc.subject | CLOPIDOGREL | - |
dc.subject | RESTENOSIS | - |
dc.subject | THROMBOSIS | - |
dc.subject | IMPACT | - |
dc.subject | TRIAL | - |
dc.title | Triple Versus Dual Antiplatelet Therapy in Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rha, Seung-Woon | - |
dc.contributor.affiliatedAuthor | Kim, Eung Ju | - |
dc.contributor.affiliatedAuthor | Park, Chang Gyu | - |
dc.contributor.affiliatedAuthor | Seo, Hong Seog | - |
dc.contributor.affiliatedAuthor | Oh, Dong Joo | - |
dc.identifier.doi | 10.1161/CIRCULATIONAHA.108.822791 | - |
dc.identifier.scopusid | 2-s2.0-67650761110 | - |
dc.identifier.wosid | 000267456700009 | - |
dc.identifier.bibliographicCitation | CIRCULATION, v.119, no.25, pp.3207 - 3214 | - |
dc.relation.isPartOf | CIRCULATION | - |
dc.citation.title | CIRCULATION | - |
dc.citation.volume | 119 | - |
dc.citation.number | 25 | - |
dc.citation.startPage | 3207 | - |
dc.citation.endPage | 3214 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | ELUTING STENT IMPLANTATION | - |
dc.subject.keywordPlus | BARE METAL STENT | - |
dc.subject.keywordPlus | PLATELET-AGGREGATION | - |
dc.subject.keywordPlus | DIABETIC-PATIENTS | - |
dc.subject.keywordPlus | CILOSTAZOL | - |
dc.subject.keywordPlus | CLOPIDOGREL | - |
dc.subject.keywordPlus | RESTENOSIS | - |
dc.subject.keywordPlus | THROMBOSIS | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordAuthor | cilostazol | - |
dc.subject.keywordAuthor | myocardial infarction | - |
dc.subject.keywordAuthor | thrombosis | - |
dc.subject.keywordAuthor | platelets | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.