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Kinetic resolution of fluorinated propargyl alcohols by lipase-catalyzed enantioselective transesterification

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dc.contributor.authorKo, Sung-Jin-
dc.contributor.authorLim, Jung Yun-
dc.contributor.authorJeon, Nan Young-
dc.contributor.authorWon, Keehoon-
dc.contributor.authorHa, Deok-Chan-
dc.contributor.authorKim, Bum Tae-
dc.contributor.authorLee, Hyuk-
dc.date.accessioned2021-09-08T16:13:30Z-
dc.date.available2021-09-08T16:13:30Z-
dc.date.created2021-06-10-
dc.date.issued2009-06-05-
dc.identifier.issn0957-4166-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/119837-
dc.description.abstractIn order to obtain optically active fluorinated propargyl alcohols, a lipase-catalyzed kinetic resolution has been carried out. The effect of lipase types, organic solvents, reaction temperature, and acyl donors was examined in the lipase-catalyzed transesterification of 1,1,1-trifluoro-4-phenyl-3-butyn-2-ol. Various enantiomerically pure fluorinated propargyl alcohols have been successfully prepared in good enantiomeric excess (>84%) by Novozym 435-catalyzed transesterification with vinyl butanoate at 60 degrees C in n-hexane. In some cases, the enantiomeric purities were excellent (>99% ee). (C) 2009 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectCANDIDA-ANTARCTICA-
dc.subjectALLYLIC ALCOHOLS-
dc.subjectPURE-
dc.subjectREDUCTION-
dc.subjectACYLATION-
dc.titleKinetic resolution of fluorinated propargyl alcohols by lipase-catalyzed enantioselective transesterification-
dc.typeArticle-
dc.contributor.affiliatedAuthorHa, Deok-Chan-
dc.identifier.doi10.1016/j.tetasy.2009.03.041-
dc.identifier.scopusid2-s2.0-66549106244-
dc.identifier.wosid000267388500005-
dc.identifier.bibliographicCitationTETRAHEDRON-ASYMMETRY, v.20, no.10, pp.1109 - 1114-
dc.relation.isPartOfTETRAHEDRON-ASYMMETRY-
dc.citation.titleTETRAHEDRON-ASYMMETRY-
dc.citation.volume20-
dc.citation.number10-
dc.citation.startPage1109-
dc.citation.endPage1114-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Inorganic & Nuclear-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.subject.keywordPlusCANDIDA-ANTARCTICA-
dc.subject.keywordPlusALLYLIC ALCOHOLS-
dc.subject.keywordPlusPURE-
dc.subject.keywordPlusREDUCTION-
dc.subject.keywordPlusACYLATION-
dc.subject.keywordAuthorkinetic resolution-
dc.subject.keywordAuthorfluorinated propargyl alcohols-
dc.subject.keywordAuthorlipase-
dc.subject.keywordAuthorenantioselective-
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