No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia
- Authors
- Lee, Heon-Jeong; Kang, Seung-Gul; Choi, Jung-Eun; Park, Young-Min; Lim, Se-Won; Rhee, Min Kyu; Kim, Seung-Hyun; Kim, Leen
- Issue Date
- 6월-2009
- Publisher
- KOREAN NEUROPSYCHIATRIC ASSOC
- Keywords
- Tardive dyskinesia; Tyrosine hydoxylase; Polymorphism
- Citation
- PSYCHIATRY INVESTIGATION, v.6, no.2, pp.108 - 111
- Indexed
- SCIE
SCOPUS
KCI
OTHER
- Journal Title
- PSYCHIATRY INVESTIGATION
- Volume
- 6
- Number
- 2
- Start Page
- 108
- End Page
- 111
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/119907
- DOI
- 10.4306/pi.2009.6.2.108
- ISSN
- 1738-3684
- Abstract
- Objective Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine biosynthesis. Because the TH Val81Met polymorphism is located in the amino-terminal regulatory domain of the tetrameric enzyme, it is a candidate marker for susceptibility to dopamine-related traits. We investigated the hypothesis that TH Val81Met polymorphism can influence susceptibility to tardive dyskinesia (TD) in schizophrenia. Methods TH Val81Met polymorphism was analyzed by PCR-based methods in 83 schizophrenic patients with TD and 126 schizophrenic patients without TD, matched for antipsychotic drug exposure and other relevant variables. Results There was no significant association of the genotype and allele frequencies determined by the TH Val81Met polymorphism between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the three genotype groups. Conclusion Within the limitations imposed by the size of the clinical sample, these findings suggest that the Val81 Met polymorphism of the TH gene does not contribute significantly to the risk for TD.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
- College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.