Gold, Poly(beta-amino ester) Nanoparticles for Small Interfering RNA Delivery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Jae-Seung | - |
dc.contributor.author | Green, Jordan J. | - |
dc.contributor.author | Love, Kevin T. | - |
dc.contributor.author | Sunshine, Joel | - |
dc.contributor.author | Langer, Robert | - |
dc.contributor.author | Anderson, Daniel G. | - |
dc.date.accessioned | 2021-09-08T16:37:03Z | - |
dc.date.available | 2021-09-08T16:37:03Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-06 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/119960 | - |
dc.description.abstract | The safe and effective delivery of RNA therapeutics remains the major barrier to their broad clinical application. Here we develop a new nanoparticulate delivery system based on inorganic particles and biodegradable polycations. First, gold nanoparticles were modified with the hydrophilic polymer poly(ethylene glycol) (PEG), and then small interfering RNA (siRNA) was conjugated to the nanoparticles via biodegradable disulfide linkages, with similar to 30 strands of siRNA per nanoparticle. The particles were then coated with a library of end-modified poly(beta-amino ester)s (PBAEs), previously identified as capable of facilitating intracellular DNA delivery. Nanoparticulate formulations developed here facilitate high levels of in vitro siRNA delivery, facilitating delivery as good or better than the commercially available lipid reagent, Lipofectamine 2000. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | POLYMER LIBRARY APPROACH | - |
dc.subject | GENE DELIVERY | - |
dc.subject | SIRNA DELIVERY | - |
dc.subject | IN-VIVO | - |
dc.subject | NONHUMAN-PRIMATES | - |
dc.subject | CELLULAR UPTAKE | - |
dc.subject | HUMAN-CELLS | - |
dc.subject | NANOTECHNOLOGY | - |
dc.subject | THERAPEUTICS | - |
dc.subject | EXPRESSION | - |
dc.title | Gold, Poly(beta-amino ester) Nanoparticles for Small Interfering RNA Delivery | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Jae-Seung | - |
dc.identifier.doi | 10.1021/nl9009793 | - |
dc.identifier.scopusid | 2-s2.0-66749180499 | - |
dc.identifier.wosid | 000266969400037 | - |
dc.identifier.bibliographicCitation | NANO LETTERS, v.9, no.6, pp.2402 - 2406 | - |
dc.relation.isPartOf | NANO LETTERS | - |
dc.citation.title | NANO LETTERS | - |
dc.citation.volume | 9 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2402 | - |
dc.citation.endPage | 2406 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | POLYMER LIBRARY APPROACH | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | SIRNA DELIVERY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | NONHUMAN-PRIMATES | - |
dc.subject.keywordPlus | CELLULAR UPTAKE | - |
dc.subject.keywordPlus | HUMAN-CELLS | - |
dc.subject.keywordPlus | NANOTECHNOLOGY | - |
dc.subject.keywordPlus | THERAPEUTICS | - |
dc.subject.keywordPlus | EXPRESSION | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.