Anti-allergic effects of white rose petal extract and anti-atopic properties of its hexane fraction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Jeong Hee | - |
dc.contributor.author | Kwon, Sang-Chul | - |
dc.contributor.author | Park, Dongsun | - |
dc.contributor.author | Shin, Sunhee | - |
dc.contributor.author | Jeong, Jae-Hyun | - |
dc.contributor.author | Park, So-Young | - |
dc.contributor.author | Hwang, Seock-Yeon | - |
dc.contributor.author | Kim, Yun-Bae | - |
dc.contributor.author | Joo, Seong Soo | - |
dc.date.accessioned | 2021-09-08T16:38:44Z | - |
dc.date.available | 2021-09-08T16:38:44Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-06 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/119969 | - |
dc.description.abstract | Rosa rugosa is a species of rose native to eastern Asia. The root of R. rugosa has been used to treat diabetes mellitus, pain and chronic inflammatory disease, and a R. rugosa petal extract has a strong anti-oxidant effect. In the present study, we examined if solvent fractions from white rose petal extract (WRPE) had any anti-allergic or anti-atopic effects not previously reported. WRPE and butanol and hexane fractions effectively reduced systemic anaphylactic reactions and anti-dinitrophenyl (DNP) IgE-mediated passive cutaneous anaphylaxis in mice, with the greatest inhibition observed for the hexane fraction. In addition, a significant reduction of scratching behavior by mice after histamine injection suggested this fraction's potential anti-allergic effect. At the cell level, the hexane fraction markedly inhibited beta-hexosaminidase release from RBL-2H3 mast cells and suppressed the expressions of mRNA interferon-gamma and interleukin-4 cytokines produced by T helper cells (type 1 and 2). These results strongly support that the hexane fraction may have an effect on atopic dermatitis, as these 2 cell types play central roles in the pathogenesis of atopic dermatitis. In conclusion, these results suggest that either the hexane fraction or one of its components may be beneficial for the treatment of allergic diseases, including atopic dermatitis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.subject | SCRATCHING BEHAVIOR | - |
dc.subject | MAST-CELL | - |
dc.subject | MEDICINAL-PLANTS | - |
dc.subject | HISTAMINE H-1 | - |
dc.subject | DERMATITIS | - |
dc.title | Anti-allergic effects of white rose petal extract and anti-atopic properties of its hexane fraction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, So-Young | - |
dc.identifier.doi | 10.1007/s12272-009-1602-6 | - |
dc.identifier.scopusid | 2-s2.0-68149179614 | - |
dc.identifier.wosid | 000267390300003 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.32, no.6, pp.823 - 830 | - |
dc.relation.isPartOf | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 32 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 823 | - |
dc.citation.endPage | 830 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001348830 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | SCRATCHING BEHAVIOR | - |
dc.subject.keywordPlus | MAST-CELL | - |
dc.subject.keywordPlus | MEDICINAL-PLANTS | - |
dc.subject.keywordPlus | HISTAMINE H-1 | - |
dc.subject.keywordPlus | DERMATITIS | - |
dc.subject.keywordAuthor | Allergy | - |
dc.subject.keywordAuthor | Atopic dermatitis | - |
dc.subject.keywordAuthor | Anaphylaxis | - |
dc.subject.keywordAuthor | beta-Hexosaminidase | - |
dc.subject.keywordAuthor | Interferon-gamma | - |
dc.subject.keywordAuthor | Interleukin-4 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.