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2-Substituted Thio- and Amino-5,8-dimethoxy-1,4-naphthoquinones as a Novel Class of Acyl-CoA: Cholestrol Acyltransferase Inhibitors
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Shen, Gui-Nan | - |
| dc.contributor.author | Choi, Ong Ho | - |
| dc.contributor.author | Gajulapati, Kondaji | - |
| dc.contributor.author | Lee, Jee Hyun | - |
| dc.contributor.author | Kim, Young Kook | - |
| dc.contributor.author | Rho, Mun Chal | - |
| dc.contributor.author | Jung, Sang-Hun | - |
| dc.contributor.author | Lee, Kyeong | - |
| dc.contributor.author | Han, Sung Sik | - |
| dc.contributor.author | Song, Gyu-Yong | - |
| dc.contributor.author | Choi, Yongseok | - |
| dc.date.accessioned | 2021-09-08T16:59:08Z | - |
| dc.date.available | 2021-09-08T16:59:08Z | - |
| dc.date.created | 2021-06-10 | - |
| dc.date.issued | 2009-05-20 | - |
| dc.identifier.issn | 0253-2964 | - |
| dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120035 | - |
| dc.description.abstract | A series of 2-alkyl or 2-arylthio-5,8-dimethoxy-1,4-naphthoquinones (2-Thio-DMNQ, 5a-s) and 2-alkylamino-5,8-dimethoxy-1,4-naphthoquinones (2-Amino-DMNQ, 6a-k) was synthesized and evaluated for their ACAT inhibitory activities. Among them, the 2-dodecylthio-DMNQ 51 and 2-isobutylamidoundodecylthio-DMNQ 5r showed the most potent ACAT inhibitory activities with IC50 value of 22.8 and 24.4 mu M, respectively. In a structure-activity relationship study, 2-thio-DMNQs with side chains of carbon number 11 similar to 15 exhibited significant ACAT inhibitory activities. | - |
| dc.language | English | - |
| dc.language.iso | en | - |
| dc.publisher | WILEY-V C H VERLAG GMBH | - |
| dc.subject | ATHEROSCLEROSIS | - |
| dc.subject | MICE | - |
| dc.title | 2-Substituted Thio- and Amino-5,8-dimethoxy-1,4-naphthoquinones as a Novel Class of Acyl-CoA: Cholestrol Acyltransferase Inhibitors | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Han, Sung Sik | - |
| dc.contributor.affiliatedAuthor | Choi, Yongseok | - |
| dc.identifier.scopusid | 2-s2.0-70349730363 | - |
| dc.identifier.wosid | 000266694600022 | - |
| dc.identifier.bibliographicCitation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.30, no.5, pp.1088 - 1092 | - |
| dc.relation.isPartOf | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
| dc.citation.title | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
| dc.citation.volume | 30 | - |
| dc.citation.number | 5 | - |
| dc.citation.startPage | 1088 | - |
| dc.citation.endPage | 1092 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.identifier.kciid | ART001524185 | - |
| dc.description.journalClass | 1 | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.description.journalRegisteredClass | kci | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
| dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
| dc.subject.keywordPlus | MICE | - |
| dc.subject.keywordAuthor | Naphthoquinones | - |
| dc.subject.keywordAuthor | Mast cells | - |
| dc.subject.keywordAuthor | Acyl CoA: Cholestrol Acyl Transferase (ACAT) | - |
| dc.subject.keywordAuthor | Structure-activity relationship | - |
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