Enhancement of 1,25-Dihydroxyvitamin D-3- and All-trans Retinoic Acid-Induced HL-60 Leukemia Cell Differentiation by Panax ginseng
DC Field | Value | Language |
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dc.contributor.author | Kim, Seung-Hyun | - |
dc.contributor.author | Cho, Seung-Sik | - |
dc.contributor.author | Simkhada, Jaya-Ram | - |
dc.contributor.author | Lee, Hyo-Jeong | - |
dc.contributor.author | Kim, Si-Wouk | - |
dc.contributor.author | Kim, Tae-Sung | - |
dc.contributor.author | Yoo, Jin-Cheol | - |
dc.date.accessioned | 2021-09-08T17:25:51Z | - |
dc.date.available | 2021-09-08T17:25:51Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-05 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120084 | - |
dc.description.abstract | Ginseng (Panax ginseng C.A. Meyer) has a wide range of therapeutic uses including cancer treatment. Human promyelocytic leukemia cells differentiate into monocytes or granulocytes when treated with 1,25-dihydroxyvitamin D-3 [1,25-(OH)(2)D-3] or all-trans retinoic acid (ATRA). Treatment of HL-60 cells with zero to 100 mu g/ml of a methanol extract of ginseng for 72h induced a small increase in cell differentiation. Surprisingly, a synergistic induction of differentiation was observed when HL-60 cells were treated with ATRA or 1,25-(OH)(2)D-3 and the extract. The inhibitors of protein kinase C (PKC) and extracellular signal-regulated kinase (ERK), but not of phosphoinositide 3-kinase (PI3-K), inhibited the HL-60 differentiation induced by the extract in combination with ATRA or I 25-(OH)(2)D-3, signifying that PKC and ERK were involved in the cell differentiation enhancement by the extract. These results suggest that the ability of a methanol extract of ginseng to enhance the differentiation potential of ATRA or 1,25-(OH)(2)D-3 may improve the ultimate outcome of acute promyelocytic leukemia therapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | ACUTE PROMYELOCYTIC LEUKEMIA | - |
dc.subject | KOREAN RED GINSENG | - |
dc.subject | TELOMERASE ACTIVITY | - |
dc.subject | INDUCTION | - |
dc.subject | CANCER | - |
dc.subject | GRANULOCYTES | - |
dc.subject | INHIBITION | - |
dc.subject | APOPTOSIS | - |
dc.subject | ISOFORMS | - |
dc.title | Enhancement of 1,25-Dihydroxyvitamin D-3- and All-trans Retinoic Acid-Induced HL-60 Leukemia Cell Differentiation by Panax ginseng | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Sung | - |
dc.identifier.doi | 10.1271/bbb.80823 | - |
dc.identifier.scopusid | 2-s2.0-67049156854 | - |
dc.identifier.wosid | 000266620100012 | - |
dc.identifier.bibliographicCitation | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.73, no.5, pp.1048 - 1053 | - |
dc.relation.isPartOf | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.title | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 73 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1048 | - |
dc.citation.endPage | 1053 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | ACUTE PROMYELOCYTIC LEUKEMIA | - |
dc.subject.keywordPlus | KOREAN RED GINSENG | - |
dc.subject.keywordPlus | TELOMERASE ACTIVITY | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | GRANULOCYTES | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | ISOFORMS | - |
dc.subject.keywordAuthor | all-trans retinoic acid | - |
dc.subject.keywordAuthor | HL-60 cells | - |
dc.subject.keywordAuthor | leukemia | - |
dc.subject.keywordAuthor | 1,25-dihydroxyvitamin in D-3 | - |
dc.subject.keywordAuthor | Panax ginseng | - |
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