Single-nucleotide polymorphisms in the promoter of the CDK5 gene and lung cancer risk in a Korean population
DC Field | Value | Language |
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dc.contributor.author | Choi, Hyo Seon | - |
dc.contributor.author | Lee, Youngin | - |
dc.contributor.author | Park, Kyong Hwa | - |
dc.contributor.author | Sung, Jae Sook | - |
dc.contributor.author | Lee, Jong-Eun | - |
dc.contributor.author | Shin, Eun-Soon | - |
dc.contributor.author | Ryu, Jeong-Seon | - |
dc.contributor.author | Kim, Yeul Hong | - |
dc.date.accessioned | 2021-09-08T17:26:42Z | - |
dc.date.available | 2021-09-08T17:26:42Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-05 | - |
dc.identifier.issn | 1434-5161 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120089 | - |
dc.description.abstract | Cyclin-dependent kinase 5 (CDK5), a proline-directed serine/threonine kinase, which was originally known for its regulatory role in neuronal activities, has recently been suggested to play a role in extraneuronal activities. For example, a recent study detected overexpression of the CDK5 gene in non-small-cell lung cancer. Therefore, in order to explore the association of the CDK5 gene with lung cancer risk in a Korean population, the genotypes of the CDK5 promoter region were determined in 407 lung cancer patients and 402 normal participants. The result showed that the -904 G>A genotype affected susceptibility to lung cancer risk (odd ratios (OR)=1.53, 95% confidence interval (CI)=1.02-2.32). Furthermore, subsequent haplotype analysis of three single-nucleotide polymorphism (SNP) regions suggested that the A-G-C haplotype was associated with a higher overall risk of lung cancer (OR=1.59, 95% CI=1.16-2.18). These results suggest that CDK5 promoter polymorphisms contribute to the genetic susceptibility to lung cancer in the Korean population. Journal of Human Genetics (2009) 54, 298-303; doi:10.1038/jhg.2009.29; published online 3 April 2009 | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CYCLIN-DEPENDENT KINASE-5 | - |
dc.subject | DIRECTED PROTEIN-KINASE | - |
dc.subject | CELL-DIFFERENTIATION | - |
dc.subject | ACTIVATOR P35NCK5A | - |
dc.subject | MONOCYTIC CELLS | - |
dc.subject | EXPRESSION | - |
dc.subject | BRAIN | - |
dc.subject | ASSOCIATION | - |
dc.subject | HAPLOTYPE | - |
dc.subject | SNPS | - |
dc.title | Single-nucleotide polymorphisms in the promoter of the CDK5 gene and lung cancer risk in a Korean population | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Kyong Hwa | - |
dc.contributor.affiliatedAuthor | Sung, Jae Sook | - |
dc.contributor.affiliatedAuthor | Kim, Yeul Hong | - |
dc.identifier.doi | 10.1038/jhg.2009.29 | - |
dc.identifier.scopusid | 2-s2.0-67649566961 | - |
dc.identifier.wosid | 000266538400008 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HUMAN GENETICS, v.54, no.5, pp.298 - 303 | - |
dc.relation.isPartOf | JOURNAL OF HUMAN GENETICS | - |
dc.citation.title | JOURNAL OF HUMAN GENETICS | - |
dc.citation.volume | 54 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 298 | - |
dc.citation.endPage | 303 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.subject.keywordPlus | CYCLIN-DEPENDENT KINASE-5 | - |
dc.subject.keywordPlus | DIRECTED PROTEIN-KINASE | - |
dc.subject.keywordPlus | CELL-DIFFERENTIATION | - |
dc.subject.keywordPlus | ACTIVATOR P35NCK5A | - |
dc.subject.keywordPlus | MONOCYTIC CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | HAPLOTYPE | - |
dc.subject.keywordPlus | SNPS | - |
dc.subject.keywordAuthor | cyclin-dependent kinase 5 (CDK5) | - |
dc.subject.keywordAuthor | lung cancer | - |
dc.subject.keywordAuthor | single-nucleotide polymorphism | - |
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