Lyn inhibits osteoclast differentiation by interfering with PLC gamma 1-mediated Ca2+ signaling
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoon, Soo-Hyun | - |
dc.contributor.author | Lee, Youngkyun | - |
dc.contributor.author | Kim, Hyung-Joon | - |
dc.contributor.author | Lee, Zang Hee | - |
dc.contributor.author | Hyung, Seok-Won | - |
dc.contributor.author | Lee, Sang-Won | - |
dc.contributor.author | Kim, Hong-Hee | - |
dc.date.accessioned | 2021-09-08T18:13:03Z | - |
dc.date.available | 2021-09-08T18:13:03Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-04-02 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120256 | - |
dc.description.abstract | Osteoclasts differentiate from macrophage-lineage cells to become specialized for bone resorption function. By a proteomics approach, we found that Lyn was down-regulated by the osteoclast differentiation factor, receptor activator of NF-kappa B ligand (RANKL). The forced reduction of Lyn caused a striking increase in the RANKL-induced PLC gamma 1, Ca2+, and NFATc1 responses during differentiation. These data suggest that Lyn plays a negative role in osteoclastogenesis by interfering with the PLC gamma 1-mediated Ca2+ signaling that leads to NFATc1 activation. Consistent with the in vitro results, in vivo injection of Lyn specific siRNA into mice calvariae provoked a fulminant bone resorption. Our study provides the first evidence of the involvement of Lyn in the negative regulation of osteoclastogenesis by RANKL. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | TYROSINE KINASE | - |
dc.subject | DEFICIENT MICE | - |
dc.subject | SYK | - |
dc.subject | RANKL | - |
dc.subject | ACTIVATION | - |
dc.subject | IMMUNE | - |
dc.subject | DAP12 | - |
dc.title | Lyn inhibits osteoclast differentiation by interfering with PLC gamma 1-mediated Ca2+ signaling | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sang-Won | - |
dc.identifier.doi | 10.1016/j.febslet.2009.03.005 | - |
dc.identifier.scopusid | 2-s2.0-63149187085 | - |
dc.identifier.wosid | 000264761800019 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, v.583, no.7, pp.1164 - 1170 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.citation.title | FEBS LETTERS | - |
dc.citation.volume | 583 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1164 | - |
dc.citation.endPage | 1170 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | TYROSINE KINASE | - |
dc.subject.keywordPlus | DEFICIENT MICE | - |
dc.subject.keywordPlus | SYK | - |
dc.subject.keywordPlus | RANKL | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | IMMUNE | - |
dc.subject.keywordPlus | DAP12 | - |
dc.subject.keywordAuthor | Osteoclast | - |
dc.subject.keywordAuthor | Lyn | - |
dc.subject.keywordAuthor | RANKL | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.