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In Vitro Anti-Adhesive Activity of Green Tea Extract against Pathogen Adhesion

Authors
Lee, Ji-HyeShim, Jin SunChung, Mi-SookLim, Seung-TaikKim, Kyung Hyun
Issue Date
Apr-2009
Publisher
WILEY
Keywords
Staphylococcus aureus; green tea; anti-adhesive; Helicobacter pylori; Propionibacterium acnes
Citation
PHYTOTHERAPY RESEARCH, v.23, no.4, pp.460 - 466
Indexed
SCIE
SCOPUS
Journal Title
PHYTOTHERAPY RESEARCH
Volume
23
Number
4
Start Page
460
End Page
466
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/120291
DOI
10.1002/ptr.2609
ISSN
0951-418X
Abstract
Camellia sinensis polysaccharide has been reported to possess anti-adhesive activity against pathogens. The present study was designed to investigate whether hot water extracts obtained from green tea leaves might inhibit pathogen adhesion to human or mouse cell lines. Green tea extract-4 (CSI-4) with the maximum yield of 4% (w/v) is composed of a major proportion of carbohydrates containing 40% uronic acids, but lack of catechins. It showed strong inhibitory activities against hemagglutination mediated by pathogens Helicobacter pylori, Propionibacterium acnes and Staphylococcus aureus with the minimum inhibitory concentrations of 0.01-0.5 mg/mL. CSI-4 further demonstrated an inhibitory effect on the adhesion of these pathogens to host cell lines with the IC50 values (50% inhibition of adhesion) of 0.14-2.3 mg/mL. It exhibited the highest activity against P. acnes, but no inhibitory effects were observed against Lactobacillus acidophilus, Bifidobacterium bifidum, Escherichia coli, or Staphylococcus epidermidis. Our results suggest that CSI-4 may exert a selective anti-adhesive effect against certain pathogenic bacteria with no adverse effects against beneficial or commensal bacteria. Copyright (C) 2008 John Wiley & Sons, Ltd.
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