Expression of ADAM33 Is a Novel Regulatory Mechanism in IL-18-Secreted Process in Gastric Cancer
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyung-Eun | - |
dc.contributor.author | Song, Hyunkeun | - |
dc.contributor.author | Hahm, Candace | - |
dc.contributor.author | Yoon, Sun Young | - |
dc.contributor.author | Park, Sunyoung | - |
dc.contributor.author | Lee, Ha-reum | - |
dc.contributor.author | Hur, Dae Young | - |
dc.contributor.author | Kim, Taesung | - |
dc.contributor.author | Kim, Cherl-hyun | - |
dc.contributor.author | Bang, Sa Ik | - |
dc.contributor.author | Bang, Jung-Wook | - |
dc.contributor.author | Park, Hyunjeong | - |
dc.contributor.author | Cho, Dae-Ho | - |
dc.date.accessioned | 2021-09-08T18:52:15Z | - |
dc.date.available | 2021-09-08T18:52:15Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-03-15 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120420 | - |
dc.description.abstract | IL-18 has recently been reported to play a critical role in tumor migration, invasion, and metastasis. Because IL-18 has various biological activities after its secretion as an 18 kDa mature form, the regulation of the IL-18 secretion process is an important step in tumor progression. This study investigated the implication of IL-18 in vascular endothelial growth factor (VEGF)-D-regulated migration, along with the role of the IL-18 secretion process. VEGF-D enhanced cell migration, which was then blocked by inhibiting IL-18. VEGF-D increased 11,48 expression and secretion, suggesting that IL-18 is a critical mediator for VEGF-D-enhanced migration. VEGF-D induced a disintegrin and metalloprotease 33 (ADAM33) expression, which has a metalloproteinase domain. VEGF-D-enhanced IL-18 secretion and cell migration were inhibited by ADAM33 knock-down. Moreover, cell proliferation was considerably reduced in ADAM33 small interfering RNA transfectants. In conclusion, ADAM33 has a key role in gastric cancer pathogenesis by up-regulating IL-18 secretion process, resulting in increased cell migration and proliferation. The Journal of Immunology, 2009, 182: 3548-3555. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.subject | NECROSIS-FACTOR-ALPHA | - |
dc.subject | GAMMA INDUCING FACTOR | - |
dc.subject | CONVERTING-ENZYME | - |
dc.subject | INTRACELLULAR MATURATION | - |
dc.subject | WEGENERS-GRANULOMATOSIS | - |
dc.subject | CATALYTIC-ACTIVITY | - |
dc.subject | INTERLEUKIN-18 | - |
dc.subject | CELLS | - |
dc.subject | DISINTEGRIN | - |
dc.subject | IL-18 | - |
dc.title | Expression of ADAM33 Is a Novel Regulatory Mechanism in IL-18-Secreted Process in Gastric Cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Taesung | - |
dc.identifier.doi | 10.4049/jimmunol.0801695 | - |
dc.identifier.scopusid | 2-s2.0-65449123823 | - |
dc.identifier.wosid | 000264084100025 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.182, no.6, pp.3548 - 3555 | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 182 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 3548 | - |
dc.citation.endPage | 3555 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | GAMMA INDUCING FACTOR | - |
dc.subject.keywordPlus | CONVERTING-ENZYME | - |
dc.subject.keywordPlus | INTRACELLULAR MATURATION | - |
dc.subject.keywordPlus | WEGENERS-GRANULOMATOSIS | - |
dc.subject.keywordPlus | CATALYTIC-ACTIVITY | - |
dc.subject.keywordPlus | INTERLEUKIN-18 | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DISINTEGRIN | - |
dc.subject.keywordPlus | IL-18 | - |
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