O-GlcNAc inhibits interaction between Sp1 and Elf-1 transcription factors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Kihong | - |
dc.contributor.author | Chang, Hyo-Ihl | - |
dc.date.accessioned | 2021-09-08T18:53:55Z | - |
dc.date.available | 2021-09-08T18:53:55Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-03-13 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120428 | - |
dc.description.abstract | The novel protein modification, O-linked N-acetylglucosamine (O-GlcNAc), plays ail important role in various aspects of cell regulation. Although most of nuclear transcription regulatory factors are modified by O-GlcNAc, O-GlcNAc effects oil transcription remain largely undefined yet. In this Study, we show that O-GlcNAc inhibits a physical interaction between Sp1 and Elf-1 transcription factors, and negatively regulates transcription of placenta and embryonic expression oncofetal protein gone (Pem). These findings Suggest that O-GlcNAc inhibits Sp1-mediated gene transcription possibly by interrupting Sp1 interaction with its cooperative factor. (C) 2009 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | N-ACETYLGLUCOSAMINE | - |
dc.subject | NUCLEOCYTOPLASMIC PROTEINS | - |
dc.subject | HOMEOBOX GENE | - |
dc.subject | GLYCOSYLATION | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | ACTIVATION | - |
dc.subject | PROTEASOME | - |
dc.subject | PROMOTER | - |
dc.subject | INSULIN | - |
dc.subject | ROLES | - |
dc.title | O-GlcNAc inhibits interaction between Sp1 and Elf-1 transcription factors | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Kihong | - |
dc.contributor.affiliatedAuthor | Chang, Hyo-Ihl | - |
dc.identifier.doi | 10.1016/j.bbrc.2009.01.121 | - |
dc.identifier.scopusid | 2-s2.0-60549087667 | - |
dc.identifier.wosid | 000264222400026 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.380, no.3, pp.569 - 574 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 380 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 569 | - |
dc.citation.endPage | 574 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | N-ACETYLGLUCOSAMINE | - |
dc.subject.keywordPlus | NUCLEOCYTOPLASMIC PROTEINS | - |
dc.subject.keywordPlus | HOMEOBOX GENE | - |
dc.subject.keywordPlus | GLYCOSYLATION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PROTEASOME | - |
dc.subject.keywordPlus | PROMOTER | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | ROLES | - |
dc.subject.keywordAuthor | Elf-1 | - |
dc.subject.keywordAuthor | O-GlcNAc | - |
dc.subject.keywordAuthor | Pem | - |
dc.subject.keywordAuthor | Sp1 | - |
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