Functional PLGA Scaffolds for Chondrogenesis of Bone-Marrow-Derived Mesenchymal Stem Cells
DC Field | Value | Language |
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dc.contributor.author | Park, Kwideok | - |
dc.contributor.author | Cho, Kyoung-Jin | - |
dc.contributor.author | Kim, Jae-Jin | - |
dc.contributor.author | Kim, Ik-Hwan | - |
dc.contributor.author | Han, Dong Keun | - |
dc.date.accessioned | 2021-09-08T18:54:34Z | - |
dc.date.available | 2021-09-08T18:54:34Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-03-10 | - |
dc.identifier.issn | 1616-5187 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120431 | - |
dc.description.abstract | Two chondrogenic factors, Dex and TGF-beta 1, were incorporated into PLGA scaffolds and their chondrogenic potential was evaluated. The Dex-loaded PLGA scaffold was grafted with AA and heparin, the heparin-immobilized one was then reacted with TGF-beta 1, yielding a PLGA/Dex-TGF (PLGA/D/T) scaffold. The scaffolds were seeded with rabbit MSCs and cultured for 4 weeks. The results show that the scaffolds including chondrogenic factors strongly upregulated the expression of cartilage-specific genes and clearly displayed type-II Collagen immunofluorescence. The functionalized PLGA scaffolds could provide an appropriate niche for chondrogenic differentiation of MSC without a constant medium supply of Dex and TGF-beta 1. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | INDUCED GRAFT-POLYMERIZATION | - |
dc.subject | GROWTH-FACTOR DELIVERY | - |
dc.subject | IN-VIVO | - |
dc.subject | TISSUE REGENERATION | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | HEPARIN | - |
dc.subject | TGF-BETA-1 | - |
dc.subject | SYSTEM | - |
dc.subject | HYDROGELS | - |
dc.subject | ADHESION | - |
dc.title | Functional PLGA Scaffolds for Chondrogenesis of Bone-Marrow-Derived Mesenchymal Stem Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Ik-Hwan | - |
dc.identifier.doi | 10.1002/mabi.200800187 | - |
dc.identifier.scopusid | 2-s2.0-65549134284 | - |
dc.identifier.wosid | 000264420500002 | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR BIOSCIENCE, v.9, no.3, pp.221 - 229 | - |
dc.relation.isPartOf | MACROMOLECULAR BIOSCIENCE | - |
dc.citation.title | MACROMOLECULAR BIOSCIENCE | - |
dc.citation.volume | 9 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 221 | - |
dc.citation.endPage | 229 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | INDUCED GRAFT-POLYMERIZATION | - |
dc.subject.keywordPlus | GROWTH-FACTOR DELIVERY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | TISSUE REGENERATION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | HEPARIN | - |
dc.subject.keywordPlus | TGF-BETA-1 | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordAuthor | drug delivery systems | - |
dc.subject.keywordAuthor | structure | - |
dc.subject.keywordAuthor | supports | - |
dc.subject.keywordAuthor | surfaces | - |
dc.subject.keywordAuthor | tissue engineering | - |
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