Blockade of Indoleamine 2,3-Dioxygenase Protects Mice against Lipopolysaccharide-Induced Endotoxin Shock
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, In Duk | - |
dc.contributor.author | Lee, Min-Goo | - |
dc.contributor.author | Chang, Jeong Hyun | - |
dc.contributor.author | Lee, Jun Sik | - |
dc.contributor.author | Jeong, Young-Il | - |
dc.contributor.author | Lee, Chang-Min | - |
dc.contributor.author | Park, Won Sun | - |
dc.contributor.author | Han, An | - |
dc.contributor.author | Seo, Su-Kil | - |
dc.contributor.author | Lee, Sang Yong | - |
dc.contributor.author | Park, Yeong-Min | - |
dc.date.accessioned | 2021-09-08T19:11:52Z | - |
dc.date.available | 2021-09-08T19:11:52Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009-03-01 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120450 | - |
dc.description.abstract | Suppression of an excessive systemic inflammatory response is a promising and potent strategy for treating endotoxic sepsis. Indoleamine 2,3-dioxygenase (IDO), which is the rate-limiting enzyme for tryptophan catabolism, may play a critical role in various inflammatory disorders. In this study, we report a critical role for IDO in the dysregulated immune response associated with endotoxin shock. We found that IDO knockout (IDO-/-) mice and 1-methyl-D-tryptophan-treated, endotoxin-shocked mice had decreased levels of the cytokines, TNF-alpha, IL-6, and IL-12, and enhanced levels of IL-10. Blockade of IDO is thought to promote host survival in LPS-induced endotoxin shock, yet little is known about the molecular mechanisms that regulate IDO expression during endotoxin shock. In vitro and in vivo, IDO expression was increased by exogenous IL-12, but decreased by exogenous IL-10 in dendritic cells and splenic dendritic cells. Interestingly, whereas LPS-induced IL-12 levels in serum were higher than those of IL-10, the balance between serum IL-12 and IL-10 following challenge became reversed in IDO-/-. or 1-methyl-D-tryptophan-treated mice. Our findings demonstrate that the detrimental immune response to endotoxin shock may occur via IDO modulation. Restoring the IL-12 and IL-10 balance by blocking IDO represents a potential strategy for sepsis treatment. The Journal of Immunology, 2009, 182: 3146-3154. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | INTERFERON-GAMMA | - |
dc.subject | SEPTIC SHOCK | - |
dc.subject | TRYPTOPHAN CATABOLISM | - |
dc.subject | TH2 RESPONSES | - |
dc.subject | IN-VIVO | - |
dc.subject | CYTOKINE | - |
dc.subject | SEPSIS | - |
dc.subject | IDO | - |
dc.subject | INTERLEUKIN-12 | - |
dc.title | Blockade of Indoleamine 2,3-Dioxygenase Protects Mice against Lipopolysaccharide-Induced Endotoxin Shock | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Min-Goo | - |
dc.identifier.doi | 10.4049/jimmunol.0803104 | - |
dc.identifier.scopusid | 2-s2.0-64849108173 | - |
dc.identifier.wosid | 000263653100067 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.182, no.5, pp.3146 - 3154 | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 182 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 3146 | - |
dc.citation.endPage | 3154 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | SEPTIC SHOCK | - |
dc.subject.keywordPlus | TRYPTOPHAN CATABOLISM | - |
dc.subject.keywordPlus | TH2 RESPONSES | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | SEPSIS | - |
dc.subject.keywordPlus | IDO | - |
dc.subject.keywordPlus | INTERLEUKIN-12 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.