Proteasome Inhibition Promotes Functional Recovery After Peripheral Nerve Reperfusion Injury
DC Field | Value | Language |
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dc.contributor.author | Park, Jong Woong | - |
dc.contributor.author | Kin, Kwang Mo | - |
dc.contributor.author | Oh, Kwang Joon | - |
dc.contributor.author | Rhyu, Im Joo | - |
dc.contributor.author | Jang, Hyon Seok | - |
dc.date.accessioned | 2021-09-08T19:18:07Z | - |
dc.date.available | 2021-09-08T19:18:07Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2009-03 | - |
dc.identifier.issn | 0022-5282 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120477 | - |
dc.description.abstract | Backgrounds: The proteasome degrades NF-kappa B blocking protein (I-kappa B) and activates NF-kappa B that plays as a key transcriptional factor to regulate inflammatory factors that are involved in the tissue reperfusion injury. This study was designed to assess whether the proteasome inhibitor can attenuate peripheral nerve ischemia/reperfusion (I/R) injury and consequently promote motor functional recovery after ischemic insult. Methods: Rat sciatic nerves were exposed to 2 hour of ischemia followed by various periods of reperfusion. Rats were administered either proteasome inhibitor (bortezomib) or phosphate-buffered saline 30 minutes before reperfusion start. Results were evaluated using a walking track test, and an isolated muscle contraction test, and by muscle weight, and histology. Results: Bortezomib treatment induced an earlier improvement in sciatic functional index and a more rapid restoration of contractile force and wet weight of extensor digitorum longus muscle. Bortezomib reduced early axonal degeneration and promoted regeneration. Conclusion: This study indicates that bortezomib; a proteasome inhibitor, is effective at promoting the functional recovery of reperfused peripheral nerve. The proteasome inhibition may play a role as one of the clinical strategy in the peripheral nervous system I/R injury with further understanding its mechanism of action. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | NITRIC-OXIDE SYNTHASE | - |
dc.subject | ISCHEMIA-REPERFUSION | - |
dc.subject | SKELETAL-MUSCLE | - |
dc.subject | LEUKOCYTE INFILTRATION | - |
dc.subject | SUPEROXIDE-DISMUTASE | - |
dc.subject | REDUCES INFARCTION | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | BRAIN INJURY | - |
dc.title | Proteasome Inhibition Promotes Functional Recovery After Peripheral Nerve Reperfusion Injury | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Jong Woong | - |
dc.contributor.affiliatedAuthor | Jang, Hyon Seok | - |
dc.identifier.doi | 10.1097/TA.0b013e3181941218 | - |
dc.identifier.scopusid | 2-s2.0-68149138149 | - |
dc.identifier.wosid | 000264259000026 | - |
dc.identifier.bibliographicCitation | JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, v.66, no.3, pp.743 - 748 | - |
dc.relation.isPartOf | JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE | - |
dc.citation.title | JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE | - |
dc.citation.volume | 66 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 743 | - |
dc.citation.endPage | 748 | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Proceedings Paper | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Critical Care Medicine | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | BRAIN INJURY | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | ISCHEMIA-REPERFUSION | - |
dc.subject.keywordPlus | SKELETAL-MUSCLE | - |
dc.subject.keywordPlus | LEUKOCYTE INFILTRATION | - |
dc.subject.keywordPlus | SUPEROXIDE-DISMUTASE | - |
dc.subject.keywordPlus | REDUCES INFARCTION | - |
dc.subject.keywordAuthor | Proteasome inhibition | - |
dc.subject.keywordAuthor | Reperfusion | - |
dc.subject.keywordAuthor | Nerve | - |
dc.subject.keywordAuthor | Rat | - |
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