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Gene expression profiles of rat olfactory bulb at developmental stage

Authors
Cho, Jae HoonJung, Hak HyunLee, Sang HakIm, Gi JungChang, JiwonKim, Seo Jin
Issue Date
15-2월-2009
Publisher
ELSEVIER
Keywords
Olfactory bulb; Development; Gene expression; Rat
Citation
JOURNAL OF NEUROSCIENCE METHODS, v.177, no.1, pp.14 - 19
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF NEUROSCIENCE METHODS
Volume
177
Number
1
Start Page
14
End Page
19
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/120577
DOI
10.1016/j.jneumeth.2008.09.012
ISSN
0165-0270
Abstract
Microarray analysis may be a useful tool to identify some candidate genes related to the development of olfactory bulbs. In the present study, gene expression profiles of olfactory bulbs from postnatal day 1 (P1) rats and postnatal day 35 (P35) rats were analyzed by oligonucleotide-microarray and expression levels of some selected genes were also confirmed by RT-PCR and in situ hybridization. 9146 genes were commonly identified in six microarray chips. Among these genes, 76 were up-regulated and 130 were down-regulated three-folds or more at P1 olfactory bulbs. Out of these 76 up-regulated genes, 24 genes were annotated based on the NCBI database of reference sequences and expression levels of these 24 genes were confirmed by RT-PCR. Among them, 2 interesting genes (neurogenic differentiation 1 and retinoid acid receptor alpha) were localized in the PI olfactory bulb by the use of in situ hybridization technique. Our results may provide basic information to identify genes associated with functional growth of olfactory bulbs. (C) 2008 Elsevier B.V. All rights reserved.
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의과대학 (의학과)
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