PKC delta-dependent functional switch of rpS3 between translation and DNA repair
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae-Sung | - |
dc.contributor.author | Kim, Hag Dong | - |
dc.contributor.author | Kim, Joon | - |
dc.date.accessioned | 2021-09-08T20:12:25Z | - |
dc.date.available | 2021-09-08T20:12:25Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2009-02 | - |
dc.identifier.issn | 0167-4889 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120659 | - |
dc.description.abstract | Ribosomal protein S3 (rpS3) is critically involved in translation as a component of the 40S ribosomal subunit and participates in the processing of DNA damage, functioning as a damage DNA endonuclease. However, it is not yet known how the function of rpS3 switches between translation and DNA repair. Here we show that PKC delta phosphorylates rpS3 resulting in its mobilization in the nucleus to repair damaged DNA. Phosphorylated rpS3 was only detected in non-ribosomal rpS3 and the repair endonuclease activity of rpS3 was increased by its phosphorylation. In addition, rpS3 knock-down cells showed more sensitivity to genotoxic stress than control cells, and this sensitivity was corrected by overexpressed wild-type rpS3 but not by phosphorylation defective rpS3. In conclusion, we propose that the destiny of rpS3 molecules between translation and DNA repair is regulated by PKC delta-dependent phosphorylation. (c) 2008 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | DAMAGE-INDUCED PHOSPHORYLATION | - |
dc.subject | ABL TYROSINE KINASE | - |
dc.subject | BREAST-CANCER CELLS | - |
dc.subject | RIBOSOMAL-PROTEIN | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | PHORBOL ESTERS | - |
dc.subject | ACTIVATION | - |
dc.subject | PATHWAY | - |
dc.subject | ERK | - |
dc.title | PKC delta-dependent functional switch of rpS3 between translation and DNA repair | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae-Sung | - |
dc.contributor.affiliatedAuthor | Kim, Joon | - |
dc.identifier.doi | 10.1016/j.bbamcr.2008.10.017 | - |
dc.identifier.wosid | 000263402600018 | - |
dc.identifier.bibliographicCitation | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v.1793, no.2, pp.395 - 405 | - |
dc.relation.isPartOf | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | - |
dc.citation.title | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | - |
dc.citation.volume | 1793 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 395 | - |
dc.citation.endPage | 405 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | DAMAGE-INDUCED PHOSPHORYLATION | - |
dc.subject.keywordPlus | ABL TYROSINE KINASE | - |
dc.subject.keywordPlus | BREAST-CANCER CELLS | - |
dc.subject.keywordPlus | RIBOSOMAL-PROTEIN | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | PHORBOL ESTERS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | ERK | - |
dc.subject.keywordAuthor | PKC delta | - |
dc.subject.keywordAuthor | rpS3 | - |
dc.subject.keywordAuthor | Src | - |
dc.subject.keywordAuthor | Endonuclease activity | - |
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