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Association of glucocorticoid receptor polymorphisms with the susceptibility to major depressive disorder and treatment responses in Korean depressive patients

Authors
Lee, Hwa-YoungKang, Rhee-HunHan, Sang-WooPaik, Jong-WooChang, Hun SooJeong, Yoo JungLee, Min-Soo
Issue Date
2월-2009
Publisher
CAMBRIDGE UNIV PRESS
Keywords
depression; glucocorticoid receptor; polymorphism; susceptibility; treatment response
Citation
ACTA NEUROPSYCHIATRICA, v.21, no.1, pp.11 - 17
Indexed
SCIE
SCOPUS
Journal Title
ACTA NEUROPSYCHIATRICA
Volume
21
Number
1
Start Page
11
End Page
17
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/120703
DOI
10.1111/j.1601-5215.2008.00342.x
ISSN
0924-2708
Abstract
Lee H-Y, Kang R-H, Han S-W, Paik J-W, Chang HS, Jeong YJ, Lee M-S. Association of glucocorticoid receptor polymorphisms with the susceptibility to major depressive disorder and treatment responses in Korean depressive patients. Major depressive disorder (MDD) is closely related to stress reactions and serotonin probably underpins the pathophysiology of MDD. Alterations of the hypothalamic-pituitary-adrenal axis at the gene level have reciprocal consequences on serotonin neurotransmission. Glucocorticoid receptor (GR) polymorphisms affect glucocorticoid sensitivity, which is associated with cortisol feedback effects. Therefore, we hypothesised that GR polymorphisms are associated with the susceptibility to MDD and predict the treatment response. Ninety-six subjects with a minimum score of 17 on the 21-item Hamilton Depression Scale (HAMD) at baseline were enrolled into the present study. The genotypes of GR (N363S, ER22/23EK, Bcl1, and TthIII1 polymorphisms) were analysed. The HAMD score was again measured after 1, 2, 4 and 8 weeks of antidepressant treatment to detect whether the therapeutic effects differed with the GR genotype. Our subjects carried no N363S or ER22/23EK genetic polymorphisms and three types of Bcl1 and TthIII1 genetic polymorphisms. The C/C genotype and C allele at Bcl1 polymorphism were more frequent in MDD patients than in normal controls (p < 0.01 and p = 0.01, respectively). The genotype distributions did not differ significantly between responders and non-responders. These results suggest that GR polymorphism cannot predict the therapeutic response after antidepressant administration. However, GR polymorphism (Bcl1) might play a role in the pathophysiology of MDD. Future studies should check this finding in larger populations with different characteristics.
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