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Ginsenosides attenuate kainic acid-induced synaptosomal oxidative stress via stimulation of adenosine A(2A) receptors in rat hippocampus

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dc.contributor.authorShin, Eun-Joo-
dc.contributor.authorKoh, Young Ho-
dc.contributor.authorKim, A-Young-
dc.contributor.authorNah, Seung-Yeoul-
dc.contributor.authorJeong, Ji Hoon-
dc.contributor.authorChae, Jong-Seok-
dc.contributor.authorKim, Sun Cheol-
dc.contributor.authorYen, Tran Phi Hoang-
dc.contributor.authorYoon, Hyoung-Jong-
dc.contributor.authorKim, Won-Ki-
dc.contributor.authorKo, Kwang-Ho-
dc.contributor.authorKim, Hyoung-Chun-
dc.date.accessioned2021-09-08T20:29:47Z-
dc.date.available2021-09-08T20:29:47Z-
dc.date.created2021-06-18-
dc.date.issued2009-01-30-
dc.identifier.issn0166-4328-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/120726-
dc.description.abstractTreatment with ginsenosides attenuated KA-induced seizures and oxidative stress in the synaptosome, and reduced synaptic vesicles at the presynaptic terminals dose-dependently. The adenosine A(2A) receptor antagonist 1,3,7-trimethyl-8-(3-chlorostyryl) xanthine reversed the ginsenoside-mediated pharmacological actions. Neither the adenosine A(1) receptor antagonist 8-cyclopentyl-1,3-dimethylxanthine nor the adenosine A(2B) receptor antagonist alloxazine affected the ginsenoside-mediated pharmacological actions. Our results suggest that ginsenosides block KA-induced synaptosomal oxidative stress, associated with hippocampal degeneration, through activation of adenosine A(2A) receptors. (c) 2008 Elsevier B.V. All rights reserved.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherELSEVIER SCIENCE BV-
dc.subjectKAINATE-INDUCED NEUROTOXICITY-
dc.subjectTEMPORAL-LOBE EPILEPSY-
dc.subjectELECTRICAL-STIMULATION-
dc.subjectACTIVATION-
dc.subjectBRAIN-
dc.subjectDOPAMINE-
dc.subjectSEIZURE-
dc.subjectRELEASE-
dc.subjectGINSENG-
dc.subjectNEURODEGENERATION-
dc.titleGinsenosides attenuate kainic acid-induced synaptosomal oxidative stress via stimulation of adenosine A(2A) receptors in rat hippocampus-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Won-Ki-
dc.identifier.doi10.1016/j.bbr.2008.08.038-
dc.identifier.scopusid2-s2.0-57649210760-
dc.identifier.wosid000262596600032-
dc.identifier.bibliographicCitationBEHAVIOURAL BRAIN RESEARCH, v.197, no.1, pp.239 - 245-
dc.relation.isPartOfBEHAVIOURAL BRAIN RESEARCH-
dc.citation.titleBEHAVIOURAL BRAIN RESEARCH-
dc.citation.volume197-
dc.citation.number1-
dc.citation.startPage239-
dc.citation.endPage245-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBehavioral Sciences-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.relation.journalWebOfScienceCategoryBehavioral Sciences-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.subject.keywordPlusKAINATE-INDUCED NEUROTOXICITY-
dc.subject.keywordPlusTEMPORAL-LOBE EPILEPSY-
dc.subject.keywordPlusELECTRICAL-STIMULATION-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusBRAIN-
dc.subject.keywordPlusDOPAMINE-
dc.subject.keywordPlusSEIZURE-
dc.subject.keywordPlusRELEASE-
dc.subject.keywordPlusGINSENG-
dc.subject.keywordPlusNEURODEGENERATION-
dc.subject.keywordAuthorGinsenosides-
dc.subject.keywordAuthorKainate-
dc.subject.keywordAuthorSynaptosome-
dc.subject.keywordAuthorOxidative stress-
dc.subject.keywordAuthorHippocampus-
dc.subject.keywordAuthorAdenosine A(2A) receptor-
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