Orexin-A increases cell surface expression of AMPA receptors in the striatum
DC Field | Value | Language |
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dc.contributor.author | Shin, Hyun Sung | - |
dc.contributor.author | Cho, Hyeong Seok | - |
dc.contributor.author | Sung, Ki-Wug | - |
dc.contributor.author | Yoon, Bong-June | - |
dc.date.accessioned | 2021-09-08T20:46:05Z | - |
dc.date.available | 2021-09-08T20:46:05Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2009-01-16 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120746 | - |
dc.description.abstract | Accumulating evidence Suggests that orexin signaling is involved in reward and motivation circuit functions. However, the underlying mechanisms are not yet fully understood. Here, we show that orexin-A potentiates AMPAR-mediated synaptic transmission in the striatum, possibly by regulating the surface expression of AMPARs. Primary culture of striatal neurons revealed increased surface expression of AMPARs following orexin-A treatment. The increase in surface-expressed AMPARs induced by orexin-A treatment was dependent on both ERK activation and the presence of extracellular Ca2+. In the cortico-striatal synapses of rat brain slices, orexin-A bath-application caused a delayed increase in the AMPAR/NMDAR EPSC ratio, suggesting that orexin-A sets in motion a series of events that lead to functional alterations in the striatal circuits. Our findings provide a potential link between the activation of orexin signaling in the striatum in response to addictive substances and neural adaptations in the reward circuitry that may mediate the long-lasting addiction-related behaviors. (C) 2008 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | COCAINE-SEEKING BEHAVIOR | - |
dc.subject | SYNAPTIC PLASTICITY | - |
dc.subject | NUCLEUS-ACCUMBENS | - |
dc.subject | MULTIPLE MECHANISMS | - |
dc.subject | HYPOCRETIN OREXIN | - |
dc.subject | NEURONS | - |
dc.subject | SENSITIZATION | - |
dc.subject | REWARD | - |
dc.title | Orexin-A increases cell surface expression of AMPA receptors in the striatum | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Yoon, Bong-June | - |
dc.identifier.doi | 10.1016/j.bbrc.2008.11.051 | - |
dc.identifier.scopusid | 2-s2.0-57849169365 | - |
dc.identifier.wosid | 000262343200017 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.378, no.3, pp.409 - 413 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 378 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 409 | - |
dc.citation.endPage | 413 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | COCAINE-SEEKING BEHAVIOR | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | NUCLEUS-ACCUMBENS | - |
dc.subject.keywordPlus | MULTIPLE MECHANISMS | - |
dc.subject.keywordPlus | HYPOCRETIN OREXIN | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | SENSITIZATION | - |
dc.subject.keywordPlus | REWARD | - |
dc.subject.keywordAuthor | Orexin-A | - |
dc.subject.keywordAuthor | AMPA receptor | - |
dc.subject.keywordAuthor | Synaptic plasticity | - |
dc.subject.keywordAuthor | Drug addiction | - |
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