Cysteine-rich 61 (CYR61) inhibits cisplatin-induced apoptosis in ovarian carcinoma cells
- Authors
- Rho, Seung Bae; Byun, Hyun-Jung; Park, Sang-Yoon; Chun, Taehoon
- Issue Date
- 1월-2009
- Publisher
- SPRINGER
- Keywords
- Anti-cancer agent; Apoptosis; Caspase; Cisplatin; Cysteine-rich 61 (CYR61); Ovarian carcinoma cell
- Citation
- BIOTECHNOLOGY LETTERS, v.31, no.1, pp.23 - 28
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOTECHNOLOGY LETTERS
- Volume
- 31
- Number
- 1
- Start Page
- 23
- End Page
- 28
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/120799
- DOI
- 10.1007/s10529-008-9845-8
- ISSN
- 0141-5492
- Abstract
- Cysteine-rich 61 (CYR61), a member of the connective tissue factor CCN (Cyr61, CTGF, Nov) family, facilitates angiogenesis by interacting with integrins. Recent observations have indicated that CYR61 also rescues cells from anti-cancer drug-mediated apoptosis but the detailed mechanism underlying the role of CYR61 during apoptosis has not been identified. To better understand the role of CYR61 during cisplatin-induced apoptosis in tumor cells, we overexpressed or inhibited CYR61 expression in human cervical cancer cells (HeLa cells) and measured cisplatin-mediated apoptosis. The results from these experiments clearly demonstrate that CYR61 prevents cisplatin-induced apoptosis by inhibiting caspase-3 activity in HeLa cells. Therefore, CYR61 may be a useful therapeutic target for cisplatin-resistant tumors.
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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