Combination chemotherapy of S-1 and taxanes in Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yeul Hong | - |
dc.contributor.author | Kim, Hoon-Kyo | - |
dc.date.accessioned | 2021-09-08T21:04:19Z | - |
dc.date.available | 2021-09-08T21:04:19Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2009-01 | - |
dc.identifier.issn | 1436-3291 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120816 | - |
dc.description.abstract | Various combination treatments incorporating S-1 are undergoing clinical trials in Korea, especially combinations with taxane, oxaliplatin, or irinotecan. In a phase I study to estimate the maximum tolerated dose of docetaxel in combination with S-1 administered at a fixed dose of 40 mg/m(2) twice daily on days 1-14 of each 3-week cycle in patients with advanced gastric cancer, 60 mg/m(2) docetaxel was declared to be the maximum tolerated dose. A phase I/II study of the same schedule of combination chemotherapy with S-1 plus docetaxel reported doses of S-1/docetaxel of 40/75 mg/m(2) as the maximum tolerated dose. In a phase I study of S-1 plus weekly docetaxel, the patients received variable doses of docetaxel administered intravenously over 1 h on days 1 and 8 and S-1 administered on days 1-14 of each 3-week cycle. The maximum-tolerated doses of S-1 and docetaxel were determined to be 45 mg/m(2) and 35 mg/m(2) in this study. A phase I/II study of docetaxel plus S-1 combination chemotherapy from Korea reported a response rate of 43.3%. Also, a phase II study of paclitaxel plus S-1 as first-line therapy in patients with advanced or relapsed gastric cancer showed an overall response rate of 49%. The most frequent significant toxicities in combination chemotherapies with taxane plus S-1 were neutropenia and febrile neutropenia. However, nonhematological toxicities were mild to moderate. A taxane plus S-1 combination regimen could be a new standard regimen for advanced gastric cancer, given its significant activity and favorable toxicity pattern. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | ADVANCED GASTRIC-CANCER | - |
dc.subject | PHASE-II TRIAL | - |
dc.subject | LOW-DOSE LEUCOVORIN | - |
dc.subject | SUPPORTIVE CARE | - |
dc.subject | INFUSIONAL 5-FLUOROURACIL | - |
dc.subject | DOCETAXEL | - |
dc.subject | PACLITAXEL | - |
dc.subject | CISPLATIN | - |
dc.subject | THERAPY | - |
dc.subject | PLUS | - |
dc.title | Combination chemotherapy of S-1 and taxanes in Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yeul Hong | - |
dc.identifier.doi | 10.1007/s10120-008-0464-9 | - |
dc.identifier.scopusid | 2-s2.0-64949134149 | - |
dc.identifier.wosid | 000262909200006 | - |
dc.identifier.bibliographicCitation | GASTRIC CANCER, v.12, pp.31 - 37 | - |
dc.relation.isPartOf | GASTRIC CANCER | - |
dc.citation.title | GASTRIC CANCER | - |
dc.citation.volume | 12 | - |
dc.citation.startPage | 31 | - |
dc.citation.endPage | 37 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | ADVANCED GASTRIC-CANCER | - |
dc.subject.keywordPlus | PHASE-II TRIAL | - |
dc.subject.keywordPlus | LOW-DOSE LEUCOVORIN | - |
dc.subject.keywordPlus | SUPPORTIVE CARE | - |
dc.subject.keywordPlus | INFUSIONAL 5-FLUOROURACIL | - |
dc.subject.keywordPlus | DOCETAXEL | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | CISPLATIN | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | PLUS | - |
dc.subject.keywordAuthor | Gastric neoplasm | - |
dc.subject.keywordAuthor | Docetaxel | - |
dc.subject.keywordAuthor | Paclitaxel | - |
dc.subject.keywordAuthor | S-1 | - |
dc.subject.keywordAuthor | Combination chemotherapy | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.