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Association Between Interleukin 1 Polymorphisms and Rheumatoid Arthritis Susceptibility: A Metaanalysis

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dc.contributor.authorLee, Young Ho-
dc.contributor.authorJi, Jong Dae-
dc.contributor.authorSong, Gwan Gyu-
dc.date.accessioned2021-09-08T21:15:19Z-
dc.date.available2021-09-08T21:15:19Z-
dc.date.issued2009-01-
dc.identifier.issn0315-162X-
dc.identifier.issn1499-2752-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/120874-
dc.description.abstractObjective. To determine whether interleukin I (IL-1) polymorphisms confer susceptibility to rheumatoid arthritis (RA). Methods. We conducted metaanalyses on associations between IL-1 polymorphisms and RA susceptibility, using fixed or random effects models. Results. A total of 18 separate comparisons were made using 10 European, 7 Asian, and I Latin American population samples. Metaanalysis of the IL-1B+3954 CC genotype revealed an association with RA in all subjects (odds ratio = 0.776, 95% confidence interval = 0.609-0.988 p = 0.040). In Asians, an association between IL-1B+3954 and RA was identified. In contrast, no association was found between the IL-1B+3954 polymorphism and RA susceptibility in European Populations. Metaanalyses of the IL-1B-511 and IL-1RN VNTR polymorphisms identified no association between these polymorphisms and RA. Conclusion. Our metaanalysis shows that the IL-1B+3954 polymorphism was associated with the development of RA, but only in Asians. (First Release Nov 1 2008; J Rheumatol 2009:36:12-15; doi: 10.3899/jrheum.080450)-
dc.format.extent4-
dc.language영어-
dc.language.isoENG-
dc.publisherJ RHEUMATOL PUBL CO-
dc.titleAssociation Between Interleukin 1 Polymorphisms and Rheumatoid Arthritis Susceptibility: A Metaanalysis-
dc.typeArticle-
dc.publisher.location캐나다-
dc.identifier.doi10.3899/jrheum.080450-
dc.identifier.scopusid2-s2.0-58149502457-
dc.identifier.wosid000262535300005-
dc.identifier.bibliographicCitationJOURNAL OF RHEUMATOLOGY, v.36, no.1, pp 12 - 15-
dc.citation.titleJOURNAL OF RHEUMATOLOGY-
dc.citation.volume36-
dc.citation.number1-
dc.citation.startPage12-
dc.citation.endPage15-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaRheumatology-
dc.relation.journalWebOfScienceCategoryRheumatology-
dc.subject.keywordPlusGENE POLYMORPHISMS-
dc.subject.keywordPlusRECEPTOR ANTAGONIST-
dc.subject.keywordPlusPLASMA-LEVELS-
dc.subject.keywordPlusSEVERITY-
dc.subject.keywordPlusIL-1RN-
dc.subject.keywordAuthorINTERLEUKIN 1-
dc.subject.keywordAuthorGENETIC POLYMORPHISM-
dc.subject.keywordAuthorRHEUMATOID ARTHRITIS-
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