Proteomic analysis of the rat vestibular nucleus complex following unilateral labyrinthectomy
DC Field | Value | Language |
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dc.contributor.author | Ban, Jae-Ho | - |
dc.contributor.author | Chang, Jiwon | - |
dc.contributor.author | Im, Gi Jung | - |
dc.contributor.author | Jung, Hak Hyun | - |
dc.date.accessioned | 2021-09-08T21:20:51Z | - |
dc.date.available | 2021-09-08T21:20:51Z | - |
dc.date.created | 2021-06-19 | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0001-6489 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/120903 | - |
dc.description.abstract | Conclusion: The appearance of some candidate proteins may be essential for compensation as spatio-temporal expression patterns and this proteomic analysis may be a useful tool to understand the molecular basis of vestibular compensation. Objective: The purpose of this study was to identify the proteins expressed in vestibular nucleus complexes (VNCs) using proteomics following unilateral labyrinthectomy. Materials and methods: Proteomic analysis was performed in VNCs of rats at 6 h, 72 h, and 7 days following unilateral labyrinthectomy in comparison to normal VNC. Twenty-seven interesting spots in both normal and study groups were selected for MALDI-TOF MS. Expression of some selected genes was confirmed by RT-PCR. Results: In all, 22 of 27 spots were matched after MALDI-TOF MS. Among these, 14 proteins were highly expressed in normal VNCs and 8 were newly expressed following labyrinthectomy. Among these 14 normal proteins, 9 were consistently expressed in both normal and labyrinthectomized VCNs, while 5 were down-regulated following labyrinthectomy. Eight were newly expressed following labyrinthectomy. Expression patterns of nine genes at RT-PCR were compatible with protein expression patterns. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | PROTEIN EXPRESSION | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | COMPENSATION | - |
dc.subject | RECEPTOR | - |
dc.subject | MECHANISMS | - |
dc.subject | SEPARATION | - |
dc.subject | RECOVERY | - |
dc.subject | CHANNEL | - |
dc.title | Proteomic analysis of the rat vestibular nucleus complex following unilateral labyrinthectomy | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jung, Hak Hyun | - |
dc.identifier.doi | 10.1080/00016480802455275 | - |
dc.identifier.scopusid | 2-s2.0-70350389742 | - |
dc.identifier.wosid | 000268957100006 | - |
dc.identifier.bibliographicCitation | ACTA OTO-LARYNGOLOGICA, v.129, no.8, pp.846 - 854 | - |
dc.relation.isPartOf | ACTA OTO-LARYNGOLOGICA | - |
dc.citation.title | ACTA OTO-LARYNGOLOGICA | - |
dc.citation.volume | 129 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 846 | - |
dc.citation.endPage | 854 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Otorhinolaryngology | - |
dc.relation.journalWebOfScienceCategory | Otorhinolaryngology | - |
dc.subject.keywordPlus | PROTEIN EXPRESSION | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | COMPENSATION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | SEPARATION | - |
dc.subject.keywordPlus | RECOVERY | - |
dc.subject.keywordPlus | CHANNEL | - |
dc.subject.keywordAuthor | Labyrinthectomy | - |
dc.subject.keywordAuthor | compensation | - |
dc.subject.keywordAuthor | proteomics | - |
dc.subject.keywordAuthor | VNC | - |
dc.subject.keywordAuthor | rat | - |
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