급성 조증 환자에서 혈소판 BDNF 농도에 대한 예비연구

Abstract

Objectives Serum and plasma BDNF levels have been shown to be decreased in patients with mood disorder such as major depressive disorder and bipolar disorder. We investigated whether platelet BDNF levels would be lower in patients with acute bipolar manic episode compared with those of normal controls. Methods BDNF levels were examined in platelet-rich plasma(PRP) and platelet-poor plasma(PPP) in 20 healthy controls and 20 hospitalized patients who were diagnosed as bipolar I disorder, most recent episode manic using a Structured Clinical Interview for DSM-IV. And severity of manic symptoms was measured using Young Mania Rating Scale(YMRS). Platelet BDNF level was calculated by subtracting PPP BDNF from PRP BDNF level, and dividing the result by the total platelet count, and it was expressed as pg/106 platelet. Results Platelet BDNF levels were significantly lower in patients with acute bipolar manic episode (4.55±3.36 pg/106 platelet) than in normal controls (6.84±2.32 pg/106 platelet)(p=0.008). However we failed to reveal the significant negative correlation between platelet BDNF levels and YMRS scores in patients with acute bipolar episode. Conclusions Our finding suggests that there is a decrease in the platelet BDNF of patients with acute bipolar manic episode.