자가 섬유아세포-히알루론산 복합체를 이용한 당뇨발의 치료Treatment of Diabetic Ulcer using Autologous Fibroblast-Hyaluronic Acid Complex
- Other Titles
- Treatment of Diabetic Ulcer using Autologous Fibroblast-Hyaluronic Acid Complex
- Authors
- 엄수진; 한승규; 구자혜; 정성호; 김우경
- Issue Date
- 2009
- Publisher
- 대한성형외과학회
- Keywords
- Diabetic foot; Fibroblast cell therapy; Hyaluronic acid; Diabetic foot; Fibroblast cell therapy; Hyaluronic acid
- Citation
- Archives of Plastic Surgery, v.36, no.5, pp.548 - 554
- Indexed
- KCI
- Journal Title
- Archives of Plastic Surgery
- Volume
- 36
- Number
- 5
- Start Page
- 548
- End Page
- 554
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/121822
- ISSN
- 2234-6163
- Abstract
- Purpose: To evaluate clinical efficacy and safety of hyaluronic acid based autologous dermal fibroblasts (Hyalograft 3D) in the treatment of diabetic foot ulcers.
Methods: A total of 28 patients with diabetic ulcers were randomized to either the control group with nonadherent foam dressings(n=14) or the treatment group with autologous tissue-engineered grafts(n=14). Weekly assessment contained vital sign checks, ulcer size measurements, and wound photos. In the 12th week, percentages of complete wound healing and mean healing times were compared. Safety was also monitored by adverse events.
Results: Complete wound healing was achieved in 84.6% of the treatment group and 23.1% of the control group(p<0.005). The mean times of closures for the treatment versus control groups were 6.1 weeks and 10.9 weeks, respectively. No adverse events related to the study treatment occurred.
Conclusion: The use of hyaluronic acid based autologous fibroblast grafts was found to be a safe and effective treatment for diabetic foot ulcers.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.