A NUP98-HOXD13 fusion gene impairs differentiation of B and T lymphocytes and leads to expansion of thymocytes with partial TCRB gene rearrangement
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, C.W. | - |
dc.contributor.author | Chung, Y.J. | - |
dc.contributor.author | Slape, C. | - |
dc.contributor.author | Aplan, P.D. | - |
dc.date.accessioned | 2021-09-09T00:29:37Z | - |
dc.date.available | 2021-09-09T00:29:37Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/121914 | - |
dc.description.abstract | Expression of a NUP98-HOXD13 (NHD13) fusion gene leads to myelodysplastic syndrome in mice. In addition to ineffective hematopoiesis, we observed that NHD13 mice were lymphopenic; the lymphopenia was due to a decrease in both T and B lymphocytes. Although the pro-B cell (B220+/CD43+) populations from the NHD13 and wild-type mice were similar, the NHD13 mice showed decreased pre-B cells (B220+/CD43-), indicating impaired differentiation at the pro-B to pre-B stage. Thymi from NHD13 mice were smaller and overexpressed Hoxa cluster genes, including Hoxa7, Hoxa9, and Hoxa10. In addition, the NHD13 thymi contained fewer thymocytes, with an increased percentage of CD4-/CD8- (double-negative (DN)) cells and a decreased percentage of CD4+/CD8+ (double-positive) cells; the DN1/DN2 population was increased and the DN3/DN4 population was decreased, suggesting a partial block at the DN2 to DN3 transition. To determine clonality of the thymocytes, we used degenerate RT-PCR to identify clonal Tcrb gene rearrangements. Five of six NHD13 thymi showed an unusual Tcrb gene rearrangement pattern with common, clonal DJ rearrangements, but distinct V-D junctions, suggesting a marked clonal expansion of thymocytes that had undergone a DJ rearrangement, but not completed a VDJ rearrangement. Taken together, these findings demonstrate that expression of the NHD13 transgene inhibits lymphoid as well as myeloid and erythroid differentiation, results in overexpression of Hoxa cluster genes, and leads to a precursor T cell lymphoblastic leukemia/lymphoma. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.subject | leukosialin | - |
dc.subject | T lymphocyte receptor beta chain | - |
dc.subject | adolescent | - |
dc.subject | animal cell | - |
dc.subject | article | - |
dc.subject | B lymphocyte | - |
dc.subject | bone marrow cell | - |
dc.subject | CD4+ T lymphocyte | - |
dc.subject | CD8+ T lymphocyte | - |
dc.subject | cell expansion | - |
dc.subject | clonal variation | - |
dc.subject | controlled study | - |
dc.subject | erythroid cell | - |
dc.subject | fusion gene | - |
dc.subject | gene | - |
dc.subject | gene overexpression | - |
dc.subject | gene rearrangement | - |
dc.subject | hematopoiesis | - |
dc.subject | Hoxa10 gene | - |
dc.subject | Hoxa7 gene | - |
dc.subject | Hoxa9 gene | - |
dc.subject | lymphatic leukemia | - |
dc.subject | lymphoblastoma | - |
dc.subject | lymphocyte differentiation | - |
dc.subject | lymphocytopenia | - |
dc.subject | mouse | - |
dc.subject | myelodysplastic syndrome | - |
dc.subject | nonhuman | - |
dc.subject | NUP98 HOXD13 gene | - |
dc.subject | pre B lymphocyte | - |
dc.subject | priority journal | - |
dc.subject | reverse transcription polymerase chain reaction | - |
dc.subject | T lymphocyte | - |
dc.subject | thymocyte | - |
dc.subject | VDJ exon | - |
dc.subject | Animals | - |
dc.subject | Apoptosis | - |
dc.subject | B-Lymphocytes | - |
dc.subject | Cell Differentiation | - |
dc.subject | Gene Expression | - |
dc.subject | Gene Rearrangement, beta-Chain T-Cell Antigen Receptor | - |
dc.subject | Homeodomain Proteins | - |
dc.subject | Mice | - |
dc.subject | Myelodysplastic Syndromes | - |
dc.subject | Nuclear Pore Complex Proteins | - |
dc.subject | Oncogene Proteins, Fusion | - |
dc.subject | Receptors, Antigen, T-Cell, alpha-beta | - |
dc.subject | T-Lymphocytes | - |
dc.subject | Thymus Gland | - |
dc.subject | Transcription Factors | - |
dc.title | A NUP98-HOXD13 fusion gene impairs differentiation of B and T lymphocytes and leads to expansion of thymocytes with partial TCRB gene rearrangement | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, C.W. | - |
dc.identifier.doi | 10.4049/jimmunol.0901121 | - |
dc.identifier.scopusid | 2-s2.0-77950542037 | - |
dc.identifier.bibliographicCitation | Journal of Immunology, v.183, no.10, pp.6227 - 6235 | - |
dc.relation.isPartOf | Journal of Immunology | - |
dc.citation.title | Journal of Immunology | - |
dc.citation.volume | 183 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 6227 | - |
dc.citation.endPage | 6235 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | leukosialin | - |
dc.subject.keywordPlus | T lymphocyte receptor beta chain | - |
dc.subject.keywordPlus | adolescent | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | B lymphocyte | - |
dc.subject.keywordPlus | bone marrow cell | - |
dc.subject.keywordPlus | CD4+ T lymphocyte | - |
dc.subject.keywordPlus | CD8+ T lymphocyte | - |
dc.subject.keywordPlus | cell expansion | - |
dc.subject.keywordPlus | clonal variation | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | erythroid cell | - |
dc.subject.keywordPlus | fusion gene | - |
dc.subject.keywordPlus | gene | - |
dc.subject.keywordPlus | gene overexpression | - |
dc.subject.keywordPlus | gene rearrangement | - |
dc.subject.keywordPlus | hematopoiesis | - |
dc.subject.keywordPlus | Hoxa10 gene | - |
dc.subject.keywordPlus | Hoxa7 gene | - |
dc.subject.keywordPlus | Hoxa9 gene | - |
dc.subject.keywordPlus | lymphatic leukemia | - |
dc.subject.keywordPlus | lymphoblastoma | - |
dc.subject.keywordPlus | lymphocyte differentiation | - |
dc.subject.keywordPlus | lymphocytopenia | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | myelodysplastic syndrome | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | NUP98 HOXD13 gene | - |
dc.subject.keywordPlus | pre B lymphocyte | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | reverse transcription polymerase chain reaction | - |
dc.subject.keywordPlus | T lymphocyte | - |
dc.subject.keywordPlus | thymocyte | - |
dc.subject.keywordPlus | VDJ exon | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Apoptosis | - |
dc.subject.keywordPlus | B-Lymphocytes | - |
dc.subject.keywordPlus | Cell Differentiation | - |
dc.subject.keywordPlus | Gene Expression | - |
dc.subject.keywordPlus | Gene Rearrangement, beta-Chain T-Cell Antigen Receptor | - |
dc.subject.keywordPlus | Homeodomain Proteins | - |
dc.subject.keywordPlus | Mice | - |
dc.subject.keywordPlus | Myelodysplastic Syndromes | - |
dc.subject.keywordPlus | Nuclear Pore Complex Proteins | - |
dc.subject.keywordPlus | Oncogene Proteins, Fusion | - |
dc.subject.keywordPlus | Receptors, Antigen, T-Cell, alpha-beta | - |
dc.subject.keywordPlus | T-Lymphocytes | - |
dc.subject.keywordPlus | Thymus Gland | - |
dc.subject.keywordPlus | Transcription Factors | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.