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Long-term efficacy and safety of aripiprazole in patients with schizophrenia, schizophreniform disorder, or schizoaffective disorder: 26-week prospective study

Authors
Kwon, Jun SooJang, Joon HwanKang, Do-HyungYoo, So YoungKim, Yong KuCho, Seong-Jin
Issue Date
2009
Publisher
WILEY-BLACKWELL PUBLISHING, INC
Keywords
aripiprazole; efficacy; long-term treatment; safety; schizophrenia
Citation
PSYCHIATRY AND CLINICAL NEUROSCIENCES, v.63, no.1, pp.73 - 81
Indexed
SCIE
SCOPUS
Journal Title
PSYCHIATRY AND CLINICAL NEUROSCIENCES
Volume
63
Number
1
Start Page
73
End Page
81
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/122107
DOI
10.1111/j.1440-1819.2008.01907.x
ISSN
1323-1316
Abstract
To date there have been no reports of long-term efficacy of aripiprazole in Asian populations. The aim of the present study was therefore to investigate the long-term efficacy, safety and tolerability of aripiprazole in a large number of patients with schizophrenia, schizophreniform disorder, or schizoaffective disorder in Korea. This study was a prospective, multicenter, single-group, 26-week open study of patients with schizophrenia, schizophreniform disorder, or schizoaffective disorder. A total of 300 Korean patients participated in the study. The primary efficacy measure was the Positive and Negative Syndrome Scale (PANSS) total score, and secondary efficacy measures included the PANSS positive and negative subscales, Clinical Global Impression-Severity of Illness (CGI-S). Tolerability and safety were assessed by monitoring the frequency and severity of treatment-emergent adverse events, extrapyramidal symptoms (EPS), vital signs, weight, and laboratory tests. Aripiprazole produced rapid and significant improvements on all efficacy measures. As evidenced by PANSS total score, PANSS positive subscales and the CGI-S scores, first-episode drug-naive patients demonstrated significantly greater efficacy relative to patients who had previously experienced one or more episodes of relapse. Aripiprazole was associated with significant decrease of serum prolactin level. The subjects showed mild weight gain. Aripiprazole is an effective antipsychotic in the long-term treatment of both positive and negative symptoms. This study extends the findings of previous long-term studies, and has found that there is no significant difference with regard to ethnicity in response to aripiprazole.
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