Formation of size-controlled nano carrier systems by self-assembly
- Authors
- Bang, S. H.; Yu, Y. M.; Hwang, I. C.; Park, H. J.
- Issue Date
- 2009
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- Phosphatidylcholine (lecithin); chitosan; alginic acid; electronic attraction; nano liposome; carrier system
- Citation
- JOURNAL OF MICROENCAPSULATION, v.26, no.8, pp.722 - 733
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF MICROENCAPSULATION
- Volume
- 26
- Number
- 8
- Start Page
- 722
- End Page
- 733
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/122139
- DOI
- 10.3109/02652040902726994
- ISSN
- 0265-2048
- Abstract
- Nano carrier systems were prepared by forming self-assembled liposomes having a size distribution in the nano range through use of an ultrasonic homogenizer. Phosphatidylcholine and cholesterol were utilized as an amphiphilic compound and a shape stabilizer, respectively. The size of prepared samples was decreased (up to 150 nm) by elevating ratio of lecithin and extending homogenization time (2 similar to 6 min). After secondary coating with alginic acid (0.1, 0.3 and 0.5%, W/V), size was remarkably changed in the range of +/-30nm and zeta-potential was altered (only chitosan coating (molecular weight: 30 000 Da, 0.2%, W/V): 10.3 mV, Alginic acid coating (0.5%, W/V) after the chitosan coating: -21.8 mV). The low molecular weight chitosan (0.1%, W/V)-coated nano-liposomes had a lower absolute value of zeta-potential than the high molecular weight chitosan (0.1%, W/V)coated nano-liposomes. The encapsulation efficiency was measured by gas chromatography. The efficiency was decreased slightly by elevating chitosan concentration (0.1 similar to 0.5%, W/V).
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Collections - Graduate School > Department of Biotechnology > 1. Journal Articles
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