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Whole blood Epstein-Barr virus DNA load as a diagnostic and prognostic surrogate: extranodal natural killer/T-cell lymphoma

Authors
Kim, Hyo SongKim, Kyung HeeKim, Kyoung HaChang, Myung HeeJi, Sang HoonLim, Do HyoungKim, KihyunKim, Seok JinKo, YounghyehKi, Chang-SeokJo, Sook JungLee, Jae WonKim, Won Seog
Issue Date
2009
Publisher
TAYLOR & FRANCIS LTD
Keywords
Epstein-Barr virus (EBV); lymphoma; whole blood; viral load
Citation
LEUKEMIA & LYMPHOMA, v.50, no.5, pp.757 - 763
Indexed
SCIE
SCOPUS
Journal Title
LEUKEMIA & LYMPHOMA
Volume
50
Number
5
Start Page
757
End Page
763
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/122142
DOI
10.1080/10428190902803669
ISSN
1042-8194
Abstract
We investigated the value of Epstein-Barr virus (EBV) DNA load in unfractionated whole blood for the diagnosis and prognosis of EBV-associated lymphoma. From July 2004 to July 2007, we compared EBV DNA loads in 101 patients with lymphoma and 105 control individuals. The median copy number of EBV was higher in patients with EBV-positive lymphoma (p0.001). In patients with natural killer (NK)/T-cell lymphomas, the median EBV DNA load at presentation was significantly related to the stage (p=0.011) and response (p=0.026). The newly proposed classification model for NK/T cell lymphoma showed EBV DNA load differed significantly between patients with upper and extra-upper aerodigestive tracts (p=0.017). In 16 patients with NK/T-cell lymphoma monitored serially, EBV DNA load correlated well with the treatment response and clinical course. Further prospective studies are required to evaluate the diagnosing and monitoring role of whole blood EBV DNA for uniformly treated patients.
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정경대학 (통계학과)
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