Different Expression of Vascular Endothelial Growth Factor and Pigment Epithelium-Derived Factor between Diabetic and Non-Diabetic Epiretinal Membranes
DC Field | Value | Language |
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dc.contributor.author | Nam, Dong Heun | - |
dc.contributor.author | Oh, Jaeryung | - |
dc.contributor.author | Roh, Joon Ho | - |
dc.contributor.author | Huh, Kuhl | - |
dc.date.accessioned | 2021-09-09T01:12:56Z | - |
dc.date.available | 2021-09-09T01:12:56Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0030-3755 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122160 | - |
dc.description.abstract | Purpose: To determine whether there is a difference in protein levels of expression of vascular endothelial growth factor ( VEGF), pigment epithelium-derived factor ( PEDF), platelet-derived growth factor ( PDGF) and transforming growth factor beta(1) (TGF-beta(1)) between diabetic and non-diabetic epiretinal membranes (ERMs). Methods: ERMs and vitreous were surgically removed from the eyes of 8 patients with proliferative diabetic retinopathy and from 6 patients with proliferative vitreoretinopathy. Concentrations of VEGF, PEDF, PDGF and TGF-beta(1) were investigated by an enzyme-linked immunosorbent assay. Results: The concentrations of VEGF were higher in ERMs from patients with diabetes (9.2 +/- 8.0 pg/mu g protein) compared to those without diabetes (1.2 +/- 3.0 pg/mu g protein; p = 0.026), while the concentrations of PEDF were higher in ERMs from patients without diabetes (7.5 +/- 1.5 ng/mu g protein) compared to those with diabetes (3.5 +/- 1.5 ng/mu g protein; p = 0.002). In addition, the VEGF-to-PEDF ratio was higher in diabetic ERMs (2.80 +/- 1.83) than in non-diabetic ones (0.17 +/- 0.09; p = 0.019). However, the concentrations of PDGF and TGF-beta(1) in membranes were not different between patients with diabetes and those without diabetes. Conclusion: This study found the difference in protein levels of expression of VEGF and PEDF between diabetic and non-diabetic ERMs. These results suggest that a disturbance in the balance between angiogenic and anti-angiogenic factors may play an important role in angiogenesis in diabetic ERMs. Copyright (C) 2009 S. Karger AG, Basel | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KARGER | - |
dc.subject | PROLIFERATIVE VITREORETINOPATHY | - |
dc.subject | IN-VITRO | - |
dc.subject | RETINOPATHY | - |
dc.subject | CELLS | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | RECEPTORS | - |
dc.title | Different Expression of Vascular Endothelial Growth Factor and Pigment Epithelium-Derived Factor between Diabetic and Non-Diabetic Epiretinal Membranes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Jaeryung | - |
dc.contributor.affiliatedAuthor | Huh, Kuhl | - |
dc.identifier.doi | 10.1159/000198686 | - |
dc.identifier.scopusid | 2-s2.0-58949095224 | - |
dc.identifier.wosid | 000265627700008 | - |
dc.identifier.bibliographicCitation | OPHTHALMOLOGICA, v.223, no.3, pp.188 - 191 | - |
dc.relation.isPartOf | OPHTHALMOLOGICA | - |
dc.citation.title | OPHTHALMOLOGICA | - |
dc.citation.volume | 223 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 188 | - |
dc.citation.endPage | 191 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.subject.keywordPlus | PROLIFERATIVE VITREORETINOPATHY | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | RETINOPATHY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | RECEPTORS | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.subject.keywordAuthor | Diabetic retinopathy | - |
dc.subject.keywordAuthor | Epiretinal membrane | - |
dc.subject.keywordAuthor | Pigment epithelium-derived factor | - |
dc.subject.keywordAuthor | Vascular endothelial growth factor | - |
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