Selective Suppression of a Subset of Bax-dependent Neuronal Death by a Cell Permeable Peptide Inhibitor of Bax, BIP
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Soo Young | - |
dc.contributor.author | Kim, Hyun | - |
dc.contributor.author | Sun, Woong | - |
dc.date.accessioned | 2021-09-09T01:22:51Z | - |
dc.date.available | 2021-09-09T01:22:51Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-12-31 | - |
dc.identifier.issn | 1976-8354 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122190 | - |
dc.description.abstract | Bax, a pro-apoptotic member of Bcl-2 family proteins, plays a central role in the mitochondria-dependent apoptosis. Apoptotic signals induce the translocation of Bax from cytosol into the mitochondria, which triggers the release of apoptogenic molecules such as cytochrome C and apoptosis-inducing factor, AIF. Bax-inhibiting peptide (BIP) is a cell permeable peptide comprised of five amino acids designed from the Bax-interaction domain of Ku70. Because BIP inhibits Bax translocation and Bax-mediated release of cytochrome C, BIP suppresses Bax-dependent apoptosis. In this study, we observed that BIP inhibited staurosporine-induced neuronal death in cultured cerebral cortex and cerebellar granule cells, but BIP failed to rescue granule cells from trophic signal deprivation-induced neuronal death, although both staurosporine-induced and trophic signal deprivation-induced neuronal death are dependent on Bax. These findings suggest that the mechanisms of the Bax activation may differ depending on the type of cell death induction, and thus BIP exhibits selective suppression of a subtype of Bax-dependent neuronal death. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | CEREBELLAR GRANULE NEURONS | - |
dc.subject | RETRACTED ARTICLE. SEE | - |
dc.subject | CYTOCHROME-C RELEASE | - |
dc.subject | BH3-ONLY PROTEINS | - |
dc.subject | BCL-2 FAMILY | - |
dc.subject | MOUSE MODEL | - |
dc.subject | PG 480 | - |
dc.subject | APOPTOSIS | - |
dc.subject | MITOCHONDRIA | - |
dc.subject | KU70 | - |
dc.title | Selective Suppression of a Subset of Bax-dependent Neuronal Death by a Cell Permeable Peptide Inhibitor of Bax, BIP | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyun | - |
dc.contributor.affiliatedAuthor | Sun, Woong | - |
dc.identifier.doi | 10.1080/19768354.2008.9647175 | - |
dc.identifier.scopusid | 2-s2.0-77955603953 | - |
dc.identifier.wosid | 000262740000004 | - |
dc.identifier.bibliographicCitation | ANIMAL CELLS AND SYSTEMS, v.12, no.4, pp.211 - 217 | - |
dc.relation.isPartOf | ANIMAL CELLS AND SYSTEMS | - |
dc.citation.title | ANIMAL CELLS AND SYSTEMS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 211 | - |
dc.citation.endPage | 217 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001301357 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Zoology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Zoology | - |
dc.subject.keywordPlus | CEREBELLAR GRANULE NEURONS | - |
dc.subject.keywordPlus | RETRACTED ARTICLE. SEE | - |
dc.subject.keywordPlus | CYTOCHROME-C RELEASE | - |
dc.subject.keywordPlus | BH3-ONLY PROTEINS | - |
dc.subject.keywordPlus | BCL-2 FAMILY | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | PG 480 | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | MITOCHONDRIA | - |
dc.subject.keywordPlus | KU70 | - |
dc.subject.keywordAuthor | Bax-inhibiting peptide (BIP) | - |
dc.subject.keywordAuthor | Bax | - |
dc.subject.keywordAuthor | cerebellar granule neuron | - |
dc.subject.keywordAuthor | neuronal apoptosis | - |
dc.subject.keywordAuthor | staurosporine | - |
dc.subject.keywordAuthor | potassium-serum deprivation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.