Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production
- Authors
- Son, Gi Hoon; Chung, Sooyoung; Choe, Han Kyoung; Kim, Hee-Dae; Baik, Sun-Mee; Lee, Hankyu; Lee, Han-Woong; Choi, Sukwoo; Sun, Woong; Kim, Hyun; Cho, Sehyung; Lee, Kun Ho; Kim, Kyungjin
- Issue Date
- 30-12월-2008
- Publisher
- NATL ACAD SCIENCES
- Keywords
- adrenal gland; steroidogenic acute regulatory protein; BMAL1
- Citation
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.105, no.52, pp.20970 - 20975
- Indexed
- SCIE
SCOPUS
- Journal Title
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Volume
- 105
- Number
- 52
- Start Page
- 20970
- End Page
- 20975
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/122195
- DOI
- 10.1073/pnas.0806962106
- ISSN
- 0027-8424
- Abstract
- Glucocorticoid (GC) is an adrenal steroid with diverse physiological effects. It undergoes a robust daily oscillation, which has been thought to be driven by the master circadian clock in the suprachiasmatic nucleus of the hypothalamus via the hypothalamus pituitary-adrenal axis. However, we show that the adrenal gland has its own clock and that the peripheral clockwork is tightly linked to steroidogenesis by the steroidogenic acute regulatory protein. Examination of mice with adrenal-specific knockdown of the canonical clock protein BMAL1 reveals that the adrenal clock machinery is required for circadian GC production. Furthermore, behavioral rhythmicity is drastically affected in these animals, together with altered expression of Period1, but not Period2, in several peripheral organs. We conclude that the adrenal peripheral clock plays an essential role in harmonizing the mammalian circadian timing system by generating a robust circadian GC rhythm.
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Collections - Graduate School > Department of Biomedical Sciences > 1. Journal Articles
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