DUB-1, a Fate Determinant of Dynein Heavy Chain in B-Lymphocytes, Is Regulated by the Ubiquitin-Proteasome Pathway
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Min-Young | - |
dc.contributor.author | Ajjappala, Brijesh S. | - |
dc.contributor.author | Kim, Myung-Sun | - |
dc.contributor.author | Oh, Yu-Kyoung | - |
dc.contributor.author | Baek, Kwang-Hyun | - |
dc.date.accessioned | 2021-09-09T01:33:50Z | - |
dc.date.available | 2021-09-09T01:33:50Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-12-15 | - |
dc.identifier.issn | 0730-2312 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122216 | - |
dc.description.abstract | Ubiquitinaiton and deubiquitination of post-translational modification play counter roles in determining the fate of protein function in eukaryotic system for maintaining the cellular homeostasis. Even though novel family members of growth-regulating deubiquitinating enzymes (DUB-1 and DUB-2) have been identified, their target proteins and functions are poorly understood. Dub genes encoding DUB-1 and DUB-2 are immediate-early genes and are induced in response to cytokine stimuli rapidly and transiently. In order to explore the possible proteins regulated by DUB-1, we performed the matrix assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) analysis Followed by immunoprecipitation. We confirmed that DUB-1 interacts with dynein heavy chain, which is known to regulate the movement of organelles and microtubule binding ability. In addition, structural and immunoprecipitation analyses revealed that DUB-1 contains a putative PEST motif and is polyubiquitinated, indicating that DUB-1 is also regulated by the ubiquitin-proteasome pathway. J. Cell. Biochem. 105: 1420-1429, 2008. (C) 2008 Wiley-Liss. Inc. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | DEUBIQUITINATING ENZYMES | - |
dc.subject | FAMILY | - |
dc.subject | DEGRADATION | - |
dc.subject | MEMBER | - |
dc.title | DUB-1, a Fate Determinant of Dynein Heavy Chain in B-Lymphocytes, Is Regulated by the Ubiquitin-Proteasome Pathway | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Oh, Yu-Kyoung | - |
dc.identifier.doi | 10.1002/jcb.21961 | - |
dc.identifier.scopusid | 2-s2.0-57349111828 | - |
dc.identifier.wosid | 000261752000010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELLULAR BIOCHEMISTRY, v.105, no.6, pp.1420 - 1429 | - |
dc.relation.isPartOf | JOURNAL OF CELLULAR BIOCHEMISTRY | - |
dc.citation.title | JOURNAL OF CELLULAR BIOCHEMISTRY | - |
dc.citation.volume | 105 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1420 | - |
dc.citation.endPage | 1429 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | DEUBIQUITINATING ENZYMES | - |
dc.subject.keywordPlus | FAMILY | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | MEMBER | - |
dc.subject.keywordAuthor | DEUBIQUITINATING ENZYME | - |
dc.subject.keywordAuthor | PEST MOTIF | - |
dc.subject.keywordAuthor | PROTEIN DEGRADATION | - |
dc.subject.keywordAuthor | UBIQUITIN SPECIFIC PROTEASE | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.