The genetic polymorphisms of HER-2 and the risk of lung cancer in a Korean population
DC Field | Value | Language |
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dc.contributor.author | Jo, Uk Hyun | - |
dc.contributor.author | Lo Han, Sle Gi | - |
dc.contributor.author | Seo, Jae Hong | - |
dc.contributor.author | Park, Kyong Hwa | - |
dc.contributor.author | Lee, Jae Won | - |
dc.contributor.author | Lee, Hyo Jung | - |
dc.contributor.author | Ryu, Jeong Seon | - |
dc.contributor.author | Kim, Yeul Hong | - |
dc.date.accessioned | 2021-09-09T01:51:57Z | - |
dc.date.available | 2021-09-09T01:51:57Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-12-04 | - |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122242 | - |
dc.description.abstract | Background: Human Epidermal Growth Factor Receptor 2 (HER-2; also known as erbB-2 or neu), a proto-oncogene of the receptor tyrosine kinase superfamily, has been associated with carcinogenesis and prognosis of human cancers, acting as a binding partner of other epidermal growth factor receptor (EGFR) family in the activation of EGFR signaling. Amplification of the HER-2 gene has been reported in lung cancer, where it has been associated with poor prognosis. In this study, we investigated whether the four polymorphisms (-3444C>T, -1985 G>T, I655A A>G and P1170A C>G) of the HER-2 gene are associated with the risk of lung cancer in Korean populations. Methods: The frequencies of 4 polymorphisms of the HER-2 gene were examined by the polymerase chain reaction-restriction fragment length polymorphism or the single-nucleotide polymorphism-identification technology assay in the 407 lung cancer patients and 407 healthy controls. Results: The frequencies of the 4 polymorphisms were not significantly different between patient and control groups in overall subjects. However, in the subgroup analysis, the 3 single nucleotide polymorphisms (-3444C>T, -1985G>T and P1170A C>G) showed statistically significant differences in the subgroups of females, non-smokers, and non-drinkers (p < 0.05). Additionally, we found the association between the risk of lung cancer and the polymorphisms of HER-2 gene in non-smoker subgroups with adenocarcinoma (p < 0.05). Conclusion: Our results suggest that the polymorphisms of the HER-2 gene are associated with an increased susceptibility to lung cancer in females, non-smokers and non-drinkers subgroups in the Korean population. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | BREAST-CANCER | - |
dc.subject | C-ERBB-2 EXPRESSION | - |
dc.subject | ERBB2 | - |
dc.subject | MUTATIONS | - |
dc.subject | SUSCEPTIBILITY | - |
dc.subject | ASSOCIATION | - |
dc.subject | ENVIRONMENT | - |
dc.subject | GEFITINIB | - |
dc.subject | PROGNOSIS | - |
dc.subject | PROTEIN | - |
dc.title | The genetic polymorphisms of HER-2 and the risk of lung cancer in a Korean population | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Seo, Jae Hong | - |
dc.contributor.affiliatedAuthor | Park, Kyong Hwa | - |
dc.contributor.affiliatedAuthor | Lee, Jae Won | - |
dc.contributor.affiliatedAuthor | Kim, Yeul Hong | - |
dc.identifier.doi | 10.1186/1471-2407-8-359 | - |
dc.identifier.scopusid | 2-s2.0-63549089818 | - |
dc.identifier.wosid | 000264913100001 | - |
dc.identifier.bibliographicCitation | BMC CANCER, v.9 | - |
dc.relation.isPartOf | BMC CANCER | - |
dc.citation.title | BMC CANCER | - |
dc.citation.volume | 9 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | C-ERBB-2 EXPRESSION | - |
dc.subject.keywordPlus | ERBB2 | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | ENVIRONMENT | - |
dc.subject.keywordPlus | GEFITINIB | - |
dc.subject.keywordPlus | PROGNOSIS | - |
dc.subject.keywordPlus | PROTEIN | - |
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