Different epithelial cleavage planes produced by various epikeratomes in epithelial laser in situ keratomileusis
- Authors
- Choi, Suk Kyue; Kim, Jin Hyoung; Lee, Doh; Lee, Jae Bum; Kim, Hyo Myung; Tchah, Hung Won; Hahn, Tae Woh; Joo, Mee; Ha, Chang Il
- Issue Date
- 12월-2008
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- JOURNAL OF CATARACT AND REFRACTIVE SURGERY, v.34, no.12, pp.2079 - 2084
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF CATARACT AND REFRACTIVE SURGERY
- Volume
- 34
- Number
- 12
- Start Page
- 2079
- End Page
- 2084
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/122260
- DOI
- 10.1016/j.jcrs.2008.08.027
- ISSN
- 0886-3350
- Abstract
- PURPOSE: To determine the anatomic cleavage planes produced by various epikeratomes in epithelial laser in situ keratomileusis (epi-LASIK). SETTING: Department of Ophthalmology, Ilsan Paik Hospital, Goyang, Korea. METHODS: Sixteen eyes (8 patients) were included in this study. Three epikeratomes, the Moria Epi-K, Centurion SES, and Amadeus II, were used to collect 4 epithelial flaps from 2 patients in the epi-LASIK procedure. Four epithelial flaps from 2 patients were also obtained by laser-assisted subepithelial keratectomy (LASEK). Immunohistochemical staining using monoclonal antibodies against integrin beta 1, integrin beta 4, laminin 5, and collagen type VII was performed. RESULTS: Immunohistochemical staining showed expression of integrin 131 and integrin 134 in all epithelial flaps. In epi-LASIK, the expression of laminin 5 and collagen type VII had a linear or dotted pattern that differed based on the epikeratome used. In the epithelial flaps obtained using LASEK, the expression of laminin 5 and collagen type VII had a dotted pattern. CONCLUSIONS: Each epikeratome yielded reproducible but different cleavage planes of corneal epithelium. The results suggest that further study is needed to elucidate the wound-healing process after epi-LASIK because different cleavage planes produced by different epikeratomes may influence the process.
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