Effects of Low-Dose Corticosteroids on the Bone Mineral Density of Patients With Rheumatoid Arthritis: A Meta-Analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, Young Ho | - |
dc.contributor.author | Woo, Jin-Hyun | - |
dc.contributor.author | Choi, Seong Jae | - |
dc.contributor.author | Ji, Jong Dae | - |
dc.contributor.author | Song, Gwan Gyu | - |
dc.date.accessioned | 2021-09-09T02:11:07Z | - |
dc.date.available | 2021-09-09T02:11:07Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-12 | - |
dc.identifier.issn | 1081-5589 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122340 | - |
dc.description.abstract | Background: The effects of long-term high-dose corticosteroids on bone mineral density (BMD) are clear, but the effects of low-dose corticosteroids in patients with rheumatoid arthritis (RA) remain controversial. The aim of this study was to assess the effects of low-dose corticosteroids on BMD in patients with RA. Methods: The authors surveyed randomized controlled studies that examined the effects of low-dose corticosteroids on BMD in patients with RA using MEDLINE and the Cochrane Controlled Trials Register and by performing manual searches. Data were collected on BMD (end-of-period or change-from-baseline) after longest recorded treatment durations. Meta-analysis was performed using a random effects model; outcomes are presented as standardized mean differences (SMDs). Results: Seven studies were included in this meta-analysis, which included 7 studies on lumbar BMD meta-analysis and 6 studies on femur BMD meta-analysis. Corticosteroids resulted in a moderate worsening in lumbar BMD compared with controls (SMD = -0.483; 95% confidence interval [Cl], - 0.815 to - 0.151, P = 0.004), whereas the femoral BMD differences were not siginificant (SMD = -0.224; 95% Cl, -0.663 to 0.215, P = 0.318). Subgroup analysis of BMD data performed on a change-from-baseline basis showed that corticosteroids had a clear effect on both lumbar and femoral BMDs (SMD = -0.354; 95% Cl, -0.620 to -0.088, P = 0.009; SMD = -0.488; 95% Cl, -0.911 to -0.065, P = 0.024, respectively). Conclusions: This meta-analysis shows BMD loss after low-dose corticosteroid treatment in patients with RA. These findings have practical implications for the long-term management of patients with RA on low-dose corticosteroids. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMJ PUBLISHING GROUP | - |
dc.subject | JOINT DESTRUCTION | - |
dc.subject | RANDOMIZED-TRIAL | - |
dc.subject | DISEASE-ACTIVITY | - |
dc.subject | CLINICAL-TRIALS | - |
dc.subject | PREDNISOLONE | - |
dc.subject | GLUCOCORTICOIDS | - |
dc.subject | THERAPY | - |
dc.subject | HAND | - |
dc.subject | BIAS | - |
dc.title | Effects of Low-Dose Corticosteroids on the Bone Mineral Density of Patients With Rheumatoid Arthritis: A Meta-Analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Young Ho | - |
dc.contributor.affiliatedAuthor | Choi, Seong Jae | - |
dc.contributor.affiliatedAuthor | Song, Gwan Gyu | - |
dc.identifier.doi | 10.2310/JIM.0b013e31818e82d7 | - |
dc.identifier.scopusid | 2-s2.0-58149331421 | - |
dc.identifier.wosid | 000261747100013 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INVESTIGATIVE MEDICINE, v.56, no.8, pp.1011 - 1018 | - |
dc.relation.isPartOf | JOURNAL OF INVESTIGATIVE MEDICINE | - |
dc.citation.title | JOURNAL OF INVESTIGATIVE MEDICINE | - |
dc.citation.volume | 56 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1011 | - |
dc.citation.endPage | 1018 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | JOINT DESTRUCTION | - |
dc.subject.keywordPlus | RANDOMIZED-TRIAL | - |
dc.subject.keywordPlus | DISEASE-ACTIVITY | - |
dc.subject.keywordPlus | CLINICAL-TRIALS | - |
dc.subject.keywordPlus | PREDNISOLONE | - |
dc.subject.keywordPlus | GLUCOCORTICOIDS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | HAND | - |
dc.subject.keywordPlus | BIAS | - |
dc.subject.keywordAuthor | corticosteroid | - |
dc.subject.keywordAuthor | bone mineral density | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
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