A Comparison of Gene Expression Profiles between Primary Human AML Cells and Therapy-related AML Cells
- Authors
- Kim, Young Hun; Kim, Hyung-Soo; Hwang, Junmo; Lee, Jinseok; Kim, Seonggon; Park, So-Young; Chang, Kyu-Tae; Kim, Kil Soo; Ryoo, Zae Young; Lee, Sanggyu
- Issue Date
- 12월-2008
- Publisher
- KOREAN SOC APPLIED PHARMACOLOGY
- Keywords
- Therapy-related AML; Gene expression; SAGE
- Citation
- BIOMOLECULES & THERAPEUTICS, v.16, no.4, pp.431 - 436
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BIOMOLECULES & THERAPEUTICS
- Volume
- 16
- Number
- 4
- Start Page
- 431
- End Page
- 436
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/122360
- DOI
- 10.4062/biomolther.2008.16.4.431
- ISSN
- 1976-9148
- Abstract
- To identify genes whose expression correlated with biological features of therapy-related AML (t-AML), we analyzed the expression profiles of de novo AML t(9;11) and t-AML t(9;11) bone marrow samples using previously published SAGE data. Three-hundred twenty-nine transcripts that satisfied statistical (P<0.05) and magnitude-of-change (>= 4-fold) criteria were identified as differentially expressed between de novo AML t(9;11) and t-AML t(9;11) cells. Of these transcripts, 301 (91%) matched known genes or ESTs and were classified according to functional categorlies (http://david.abcc.ncifcrf.gov/). The majority of differentially expressed genes in t-AML t(9;11) were involved in the regulation of biological and metabolic processes. Especially prominent among these were genes related to immune and drug responses. These results establish a framework for developing new drugs for the treatment of t-AML.
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