Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rho, Seung Bae | - |
dc.contributor.author | Byun, Hyun-Jung | - |
dc.contributor.author | Park, Sang-Yoon | - |
dc.contributor.author | Chun, Taehoon | - |
dc.date.accessioned | 2021-09-09T02:23:50Z | - |
dc.date.available | 2021-09-09T02:23:50Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-11-28 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122379 | - |
dc.description.abstract | Since calpain 6 is overexpressed in uterine cervical cancer tissue compared to normal tissue, we sought to define the role of calpain 6 during tumorigenesis. We overexpressed calpain 6 or inhibited calpain 6 in human cervical cancer cells (HeLa cells) and human umbilical vein endothelial cells (HUVECs), and measured cisplatin-mediated apoptosis and VEGF-mediated angiogenesis. The results indicated that calpain 6 supported tumorigenesis by inhibiting apoptosis and facilitating angiogenesis. To our knowledge, this result is the first evidence implicating calpain 6 in tumorigenesis, and it reveals calpain 6 as a novel therapeutic target for certain types of cancers. (c) 2008 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.subject | DIFFERENTIAL GENE-EXPRESSION | - |
dc.subject | CISPLATIN-INDUCED APOPTOSIS | - |
dc.subject | CELL | - |
dc.subject | HETERODIMER | - |
dc.subject | SYSTEM | - |
dc.title | Calpain 6 supports tumorigenesis by inhibiting apoptosis and facilitating angiogenesis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Chun, Taehoon | - |
dc.identifier.doi | 10.1016/j.canlet.2008.06.020 | - |
dc.identifier.scopusid | 2-s2.0-53449095522 | - |
dc.identifier.wosid | 000261010300013 | - |
dc.identifier.bibliographicCitation | CANCER LETTERS, v.271, no.2, pp.306 - 313 | - |
dc.relation.isPartOf | CANCER LETTERS | - |
dc.citation.title | CANCER LETTERS | - |
dc.citation.volume | 271 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 306 | - |
dc.citation.endPage | 313 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | DIFFERENTIAL GENE-EXPRESSION | - |
dc.subject.keywordPlus | CISPLATIN-INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | HETERODIMER | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Calpain 6 | - |
dc.subject.keywordAuthor | Endothelial cell | - |
dc.subject.keywordAuthor | Ovarian carcinoma cell | - |
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