A hantavirus causing hemorrhagic fever with renal syndrome requires gC1qR/p32 for efficient cell binding and infection
DC Field | Value | Language |
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dc.contributor.author | Choi, Yun | - |
dc.contributor.author | Kwon, Young-Chan | - |
dc.contributor.author | Kim, Soo-In | - |
dc.contributor.author | Park, Jung-Min | - |
dc.contributor.author | Lee, Kyung-Hee | - |
dc.contributor.author | Ahn, Byung-Yoon | - |
dc.date.accessioned | 2021-09-09T02:34:01Z | - |
dc.date.available | 2021-09-09T02:34:01Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-11-25 | - |
dc.identifier.issn | 0042-6822 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122385 | - |
dc.description.abstract | Hantaan virus (HTNV) is a pathogenic hantavirus that causes hemorrhagic fever with renal syndrome (HFRS). HTNV infection is mediated by alpha v beta 3 integrin. We used protein blots of Vero E6 cell homogenates to demonstrate that radiolabeled HTNV virions bind to gC1qR/p32, the acidic 32-kDa protein known as the receptor for the globular head domain of complement C1q. RNAi-mediated suppression of gC1qR/p32 markedly reduced HTNV binding and infection in human lung epithelial A549 cells. Conversely, transient expression of either simian or human gC1qR/p32 rendered non-permissive CHO cells susceptible to HTNV infection. These results suggest an important role for gC1qR/p32 in HTNV infection and pathogenesis. (C) 2008 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | GLOBULAR HEADS | - |
dc.subject | C1Q RECEPTORS | - |
dc.subject | PROTEIN | - |
dc.subject | SURFACE | - |
dc.subject | IDENTIFICATION | - |
dc.subject | GC1Q-R | - |
dc.subject | P-32 | - |
dc.subject | LOCALIZATION | - |
dc.subject | IDENTITY | - |
dc.subject | CLONING | - |
dc.title | A hantavirus causing hemorrhagic fever with renal syndrome requires gC1qR/p32 for efficient cell binding and infection | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahn, Byung-Yoon | - |
dc.identifier.doi | 10.1016/j.virol.2008.08.035 | - |
dc.identifier.scopusid | 2-s2.0-54549083102 | - |
dc.identifier.wosid | 000260841500004 | - |
dc.identifier.bibliographicCitation | VIROLOGY, v.381, no.2, pp.178 - 183 | - |
dc.relation.isPartOf | VIROLOGY | - |
dc.citation.title | VIROLOGY | - |
dc.citation.volume | 381 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 178 | - |
dc.citation.endPage | 183 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | GLOBULAR HEADS | - |
dc.subject.keywordPlus | C1Q RECEPTORS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | GC1Q-R | - |
dc.subject.keywordPlus | P-32 | - |
dc.subject.keywordPlus | LOCALIZATION | - |
dc.subject.keywordPlus | IDENTITY | - |
dc.subject.keywordPlus | CLONING | - |
dc.subject.keywordAuthor | Hantavirus | - |
dc.subject.keywordAuthor | gC1qR/p32 | - |
dc.subject.keywordAuthor | Viral binding | - |
dc.subject.keywordAuthor | Infection | - |
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