Gene transfer of AIMP1 and B7.1 into epitope-loaded, fibroblasts induces tumor-specific CTL immunity, and prolongs the survival period of tumor-bearing mice
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae S. | - |
dc.contributor.author | Lee, Byeong C. | - |
dc.contributor.author | Kim, Eugene | - |
dc.contributor.author | Cho, Daeho | - |
dc.contributor.author | Cohen, Edward P. | - |
dc.date.accessioned | 2021-09-09T02:48:20Z | - |
dc.date.available | 2021-09-09T02:48:20Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-11-05 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122415 | - |
dc.description.abstract | T helper type I (Th1) cell-mediated immune responses play Various roles in cellular immunity, including inducing cytotoxic T lymphocytes (CTLs) and they have been shown to be crucial in cancer immunotherapy. Previously, we found that aminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1) stimulated antigen-presenting cells to secrete IL-12, leading to enhanced Th I cell responses. In this Study, as a way of enhancing antigen-specific Th1 responses, mouse fibroblasts (H-2(b)) were genetically modified to express an AIMP I and a costimulatory B7.1 (Fb/AIMP1/B7.1). Fb/AIMP1/B7.1 cells were then loaded with an ovalbumin epitope as a model antigen (Fb/AIMP1/B7.1/OVA), and tested to determine if they induced OVA-specific cas in C57BL/6 mice (H-2(b)). Immunization with Fb/AIMP1/B7.1/OVA cells induced strong cytotoxic activities against OVA-expressing EG7 tumor cells, but not against other H-2(b) tumor cells. The levels of the cytotoxic response in the immunized mice with Fb/AIMP1/137.1/OVA cells were significantly higher than the responses in mice immunized with other cell constructs. CD8(+) T cells were a major cell-type of OVA-specific antitumor immunity induced by Fb/AIMP1/B7.1/OVA cells. Furthermore, treatment with Fb/AIMP1/B7.1/OVA cells significantly prolonged the survival period of EG7 tumor-bearing mice. These results indicate that AIMP1-secreting, epitope-loaded fibroblasts efficiently induce antigen-specific CTL responses in mice. (C) 2008 Elsevier Ltd. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | ANTITUMOR IMMUNITY | - |
dc.subject | DENDRITIC CELLS | - |
dc.subject | IN-VIVO | - |
dc.subject | ANTIGEN PRESENTATION | - |
dc.subject | CROSS-PRESENTATION | - |
dc.subject | CANCER | - |
dc.subject | EXPRESSION | - |
dc.subject | IMMUNOTHERAPY | - |
dc.subject | COSTIMULATION | - |
dc.subject | CARCINOMA | - |
dc.title | Gene transfer of AIMP1 and B7.1 into epitope-loaded, fibroblasts induces tumor-specific CTL immunity, and prolongs the survival period of tumor-bearing mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Tae S. | - |
dc.identifier.doi | 10.1016/j.vaccine.2008.08.051 | - |
dc.identifier.scopusid | 2-s2.0-55049085234 | - |
dc.identifier.wosid | 000261750200007 | - |
dc.identifier.bibliographicCitation | VACCINE, v.26, no.47, pp.5928 - 5934 | - |
dc.relation.isPartOf | VACCINE | - |
dc.citation.title | VACCINE | - |
dc.citation.volume | 26 | - |
dc.citation.number | 47 | - |
dc.citation.startPage | 5928 | - |
dc.citation.endPage | 5934 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | ANTITUMOR IMMUNITY | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ANTIGEN PRESENTATION | - |
dc.subject.keywordPlus | CROSS-PRESENTATION | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | COSTIMULATION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordAuthor | Fibroblast | - |
dc.subject.keywordAuthor | AIMP1 | - |
dc.subject.keywordAuthor | B7.1 | - |
dc.subject.keywordAuthor | Tumor immunity | - |
dc.subject.keywordAuthor | Vaccine | - |
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