In Situ Detection of Live Cancer Cells by Using Bioprobes Based on Au Nanoparticles
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Jaemoon | - |
dc.contributor.author | Eom, Kilho | - |
dc.contributor.author | Lim, Eun-Kyung | - |
dc.contributor.author | Park, Jinsung | - |
dc.contributor.author | Kang, Yoonah | - |
dc.contributor.author | Yoon, Dae Sung | - |
dc.contributor.author | Na, Sungsoo | - |
dc.contributor.author | Koh, Eui Kwan | - |
dc.contributor.author | Suh, Jin-Suck | - |
dc.contributor.author | Huh, Yong-Min | - |
dc.contributor.author | Kwon, Tae Yun | - |
dc.contributor.author | Haam, Seungjoo | - |
dc.date.accessioned | 2021-09-09T02:48:41Z | - |
dc.date.available | 2021-09-09T02:48:41Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-11-04 | - |
dc.identifier.issn | 0743-7463 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122417 | - |
dc.description.abstract | We fabricate the high-performance probes based on Au nanoparticles (AuNP) for detection of live cancer cell. AuNP were synthesized with narrow sized distribution (ca. 10 nm) by Au salt reduction method and deposited onto the aminated substrate as a cross-linker and hot spot. Herein, AuNP has enabled the easy and efficient immobilization of the antibody (Cetuximab), which can selectively interact with epidermal growth factor receptor (EGFR) on the surface of epidermal cancer, as detecting moiety onto the AuNP-deposited substrate without nanolithography process. After conjugation of Cetuximab with AuNP-deposited substrate, Cetuximab-conjugated probe as a live cancer cell detector (LCCD) could detect EGFR-highexpressed A431 cells related to epithelial cancer with 54-times larger specificity and sensitivity in comparison with EGFR-deficient MCF7 cells. This implies that AuNP-based probes demonstrate abundant potentials for detection and separation of small biomolecules, cells and other chemicals. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | ATOMIC-FORCE MICROSCOPY | - |
dc.subject | MAGNETIC NANOPARTICLES | - |
dc.subject | GOLD NANORODS | - |
dc.subject | DNA DETECTION | - |
dc.subject | NANOLITHOGRAPHY | - |
dc.subject | SILICON | - |
dc.title | In Situ Detection of Live Cancer Cells by Using Bioprobes Based on Au Nanoparticles | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Na, Sungsoo | - |
dc.contributor.affiliatedAuthor | Kwon, Tae Yun | - |
dc.identifier.doi | 10.1021/la802184m | - |
dc.identifier.scopusid | 2-s2.0-56449128288 | - |
dc.identifier.wosid | 000260508800005 | - |
dc.identifier.bibliographicCitation | LANGMUIR, v.24, no.21, pp.12112 - 12115 | - |
dc.relation.isPartOf | LANGMUIR | - |
dc.citation.title | LANGMUIR | - |
dc.citation.volume | 24 | - |
dc.citation.number | 21 | - |
dc.citation.startPage | 12112 | - |
dc.citation.endPage | 12115 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | ATOMIC-FORCE MICROSCOPY | - |
dc.subject.keywordPlus | MAGNETIC NANOPARTICLES | - |
dc.subject.keywordPlus | GOLD NANORODS | - |
dc.subject.keywordPlus | DNA DETECTION | - |
dc.subject.keywordPlus | NANOLITHOGRAPHY | - |
dc.subject.keywordPlus | SILICON | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.