Synthesis and characterization of matrix metalloprotease sensitive-low molecular weight hyaluronic acid based hydrogels
DC Field | Value | Language |
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dc.contributor.author | Kim, Jungju | - |
dc.contributor.author | Park, Yongdoo | - |
dc.contributor.author | Tae, Giyoong | - |
dc.contributor.author | Lee, Kyu Back | - |
dc.contributor.author | Hwang, Soon Jung | - |
dc.contributor.author | Kim, In Sook | - |
dc.contributor.author | Noh, Insup | - |
dc.contributor.author | Sun, Kyung | - |
dc.date.accessioned | 2021-09-09T02:55:40Z | - |
dc.date.available | 2021-09-09T02:55:40Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-11 | - |
dc.identifier.issn | 0957-4530 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122454 | - |
dc.description.abstract | Hyaluronic acid is a naturally derived glycosaminoglycan (GAG) involved in biological processes. A low molecular weight hyaluronic acid (50 kDa)-based hydrogel was synthesized using acrylated hyaluronic acid. Matrix metalloproteinase (MMP) sensitive hyaluronic acid-based hydrogels were prepared by conjugation with two different peptides: cell adhesion peptides containing integrin binding domains (Arg-Gly-Asp: RGD) and a cross-linker with MMP degradable peptides to mimic the remodeling characteristics of natural extracellular matrices (ECMs) by cell-derived MMPs. Mechanical properties of these hydrogels were evaluated with different molecular weights of acrylated hyaluronic acid (10 kDa and 50 kDa) cross-linked by MMP sensitive peptides by measuring elastic modulus, viscous modulus, swelling ratio and degradation rate. The MMP sensitive hydrogel based on the 50 kDa hyaluronic acid showed a 31.5-fold shorter gelation time, 4.7-fold higher storage modulus and 0.51-fold smaller swelling ratio than those of the hydrogel based on the 10 kDa. Degradation rate was dependent on MMP sensitivity of the peptide cross-linker. MMP sensitive hyaluronic acid based hydrogels were degraded faster than MMP insensitive-hyaluronic acid-based hydrogels. Human mesenchymal stem cells (MSCs) were cultured in MMP-sensitive or insensitive hyaluronic acid-based hydrogels (50 kDa hyaluronic acid) and/or immobilized cell adhesive RGD peptides. Cells cultured in the MMP-sensitive hydrogel with RGD peptides showed dramatic cell spreading compared with that of the control, which remained round. This MMP-sensitive low molecular weight hyaluronic acid-based hydrogel could be useful in tissue engineering by improving tissue defect regeneration and tissue remodeling. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | CHEMICAL-MODIFICATION | - |
dc.subject | DRUG-DELIVERY | - |
dc.subject | TISSUE | - |
dc.subject | MIGRATION | - |
dc.subject | DERIVATIVES | - |
dc.subject | GROWTH | - |
dc.subject | CD44 | - |
dc.subject | BIODEGRADATION | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | CELLS | - |
dc.title | Synthesis and characterization of matrix metalloprotease sensitive-low molecular weight hyaluronic acid based hydrogels | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Yongdoo | - |
dc.contributor.affiliatedAuthor | Lee, Kyu Back | - |
dc.contributor.affiliatedAuthor | Sun, Kyung | - |
dc.identifier.doi | 10.1007/s10856-008-3469-3 | - |
dc.identifier.scopusid | 2-s2.0-51649124215 | - |
dc.identifier.wosid | 000259127200001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v.19, no.11, pp.3311 - 3318 | - |
dc.relation.isPartOf | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | - |
dc.citation.title | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | - |
dc.citation.volume | 19 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3311 | - |
dc.citation.endPage | 3318 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | CHEMICAL-MODIFICATION | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | TISSUE | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | CD44 | - |
dc.subject.keywordPlus | BIODEGRADATION | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | CELLS | - |
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