Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model
DC Field | Value | Language |
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dc.contributor.author | Choi, Yongseok | - |
dc.contributor.author | Park, Song-Kyu | - |
dc.contributor.author | Kim, Hwan Mook | - |
dc.contributor.author | Kang, Jong Soon | - |
dc.contributor.author | Yoon, Yeo Dae | - |
dc.contributor.author | Han, Sang Bae | - |
dc.contributor.author | Han, Jeung Whan | - |
dc.contributor.author | Yang, Jee Sun | - |
dc.contributor.author | Han, Gyoonhee | - |
dc.date.accessioned | 2021-09-09T03:15:37Z | - |
dc.date.available | 2021-09-09T03:15:37Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-10-31 | - |
dc.identifier.issn | 1226-3613 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122532 | - |
dc.description.abstract | In light of the anti-inflammatory properties of histone deacetylase (HDAC) inhibitors, such as suberoylanilide hydroxamic acid (SAHA) and trichostatin A (TSA), we examined a new HDAC inhibitor KBH-A42 for its anti-inflammatory activities. KBH-A42 showed noteworthy anti-inflammatory properties in vitro via suppression of the production of TNF-alpha, a proinflammatory cytokine, and nitric oxide (NO), a proinflammatory effector molecule, in LPS-stimulated RAW264.7 cells and peritoneal macrophages. It also inhibited TNF-alpha production in vivo as demonstrated in a LPS-induced mouse endotoxemia model. The levels of TNF-alpha, IL-1 beta, IL-6 and iNOS mRNAs determined by RT-PCR propose that the inhibition of these pro-inflammatory mediators by KBH-A42 resulted from inhibiting expression of these genes. However, the EMSA study to see the effect of KBH-A42 on the binding of NF-kappa B, a transcription factor, to a specific DNA sequence showed that the binding of NF-kappa B to DNA was not changed regardless of increasing the concentration of KBH-A42 in the presence and absence of LIPS stimulation. Interestingly, DNA binding of another transcription factor AP-1 dose-dependently increased by KBH-A42. KBH-A42 differentially regulated the phosphorylation of MAP kinases. While the phosphprylation of ERK1/2 and SAPK/JNK was not affected by KBH-A42, the phosphorylation of p38 decreased by KBH-A42. These results showed that KBH-A42 inhibits production of proinflammatory cytokines in macrophages by decreasing their mRNA levels, and p38 kinase is involved in the KBH-A42-mediated inhibition. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | SUBEROYLANILIDE HYDROXAMIC ACID | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | RHEUMATOID-ARTHRITIS | - |
dc.subject | GROWTH-INHIBITION | - |
dc.subject | UP-REGULATION | - |
dc.subject | CANCER CELLS | - |
dc.subject | TNF-ALPHA | - |
dc.subject | BUTYRATE | - |
dc.subject | PROLIFERATION | - |
dc.subject | SUPPRESSION | - |
dc.title | Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Yongseok | - |
dc.contributor.affiliatedAuthor | Park, Song-Kyu | - |
dc.contributor.affiliatedAuthor | Kim, Hwan Mook | - |
dc.identifier.doi | 10.3858/emm.2008.40.5.574 | - |
dc.identifier.scopusid | 2-s2.0-57349114027 | - |
dc.identifier.wosid | 000260790900012 | - |
dc.identifier.bibliographicCitation | EXPERIMENTAL AND MOLECULAR MEDICINE, v.40, no.5, pp.574 - 581 | - |
dc.relation.isPartOf | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.title | EXPERIMENTAL AND MOLECULAR MEDICINE | - |
dc.citation.volume | 40 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 574 | - |
dc.citation.endPage | 581 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001289110 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | SUBEROYLANILIDE HYDROXAMIC ACID | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | RHEUMATOID-ARTHRITIS | - |
dc.subject.keywordPlus | GROWTH-INHIBITION | - |
dc.subject.keywordPlus | UP-REGULATION | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | BUTYRATE | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordAuthor | anti-inflammatory agents | - |
dc.subject.keywordAuthor | histone deacetylases | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | nitric oxide | - |
dc.subject.keywordAuthor | transcription factor AP-1 | - |
dc.subject.keywordAuthor | tumor necrosis factor-alpha | - |
dc.subject.keywordAuthor | vorinostat | - |
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