Self-assembly of Protein Nanoarrays on Block Copolymer Templates
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lau, K. H. Aaron | - |
dc.contributor.author | Bang, Joona | - |
dc.contributor.author | Kim, Dong Ha | - |
dc.contributor.author | Knoll, Wolfgang | - |
dc.date.accessioned | 2021-09-09T03:30:53Z | - |
dc.date.available | 2021-09-09T03:30:53Z | - |
dc.date.created | 2021-06-10 | - |
dc.date.issued | 2008-10-23 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/122543 | - |
dc.description.abstract | There is considerable interest in developing functional protein arrays on the nanoscale for high-throughput protein-based array technology, and for the study of biomolecular and cell interactions at the physical scale of the biomolecules. To these ends, self-assembly based techniques may be desirable for the nanopatterning of proteins on large sample areas without the use of lithography equipment. We present a fast, general approach for patterning proteins (and potentially other biomolecules) on the nanoscale, which takes advantage of the ability of block copolymers to self-assemble into ordered surface nanopatterns with defined chemical heterogeneity. We demonstrate nanoarrays of immunoglobulin and bovine serum albumin on polystyrene-block-poly(methyl methacrylate) templates, and illustrate the applicability of our technique through immunoassays and DNA sensing performed on the protein nanoarrays. Furthermore, we show that the pattern formation mechanism is a nanoscale effect originating from a combination of fluid flow forces and geometric restrictions templated by an underlying nanopattern with a difference in protein adsorption behavior on adjacent, chemically distinct surfaces. This understanding may provide a framework for extending the patterning approach to other proteins and material systems. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | ATOMIC-FORCE MICROSCOPY | - |
dc.subject | DIP-PEN NANOLITHOGRAPHY | - |
dc.subject | PARALLEL CHEMICAL SYNTHESIS | - |
dc.subject | THIN-FILMS | - |
dc.subject | ADSORPTION-KINETICS | - |
dc.subject | POLYMER SURFACES | - |
dc.subject | SERUM-ALBUMIN | - |
dc.subject | MOLECULAR RECOGNITION | - |
dc.subject | MONOCLONAL-ANTIBODY | - |
dc.subject | DIBLOCK COPOLYMERS | - |
dc.title | Self-assembly of Protein Nanoarrays on Block Copolymer Templates | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Bang, Joona | - |
dc.identifier.doi | 10.1002/adfm.200800487 | - |
dc.identifier.scopusid | 2-s2.0-55349142167 | - |
dc.identifier.wosid | 000260707300006 | - |
dc.identifier.bibliographicCitation | ADVANCED FUNCTIONAL MATERIALS, v.18, no.20, pp.3148 - 3157 | - |
dc.relation.isPartOf | ADVANCED FUNCTIONAL MATERIALS | - |
dc.citation.title | ADVANCED FUNCTIONAL MATERIALS | - |
dc.citation.volume | 18 | - |
dc.citation.number | 20 | - |
dc.citation.startPage | 3148 | - |
dc.citation.endPage | 3157 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | ATOMIC-FORCE MICROSCOPY | - |
dc.subject.keywordPlus | DIP-PEN NANOLITHOGRAPHY | - |
dc.subject.keywordPlus | PARALLEL CHEMICAL SYNTHESIS | - |
dc.subject.keywordPlus | THIN-FILMS | - |
dc.subject.keywordPlus | ADSORPTION-KINETICS | - |
dc.subject.keywordPlus | POLYMER SURFACES | - |
dc.subject.keywordPlus | SERUM-ALBUMIN | - |
dc.subject.keywordPlus | MOLECULAR RECOGNITION | - |
dc.subject.keywordPlus | MONOCLONAL-ANTIBODY | - |
dc.subject.keywordPlus | DIBLOCK COPOLYMERS | - |
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